TTP-mediated regulation of mRNA stability in immune cells contributes to adaptive immunity, immune tolerance and clinical applications. 2021

Yiwei Zhang, and Jian Zhou, and Zhiyuan Wei, and Hui Dong, and Di Yang, and Yuanyu Deng, and Jiahui Li, and Saiyu Shi, and Yi Sun, and Huimin Lu, and Jizhao Yuan, and Bing Ni, and Yuzhang Wu, and Yi Tian, and Chao Han
Institute of Immunology, PLA, Third Military Medical University (Army Medical University), Chongqing, PR China.

Dendritic cells (DCs) form a sentinel network to induce protective immunity against pathogens or self-tolerance. mRNA stability is an important part of the post-transcriptional regulation (PTR) that controls the maturation and function of DCs. In this review, we summarize the effects of TTP-mediated regulation of mRNA stability in DCs, focusing on DC maturation and antigen presentation, T cell activation and differentiation, immune tolerance and inflammation. We also discuss the potential DC-based immune treatment for HIV+ patients through regulation of mRNA stability. This review proposes the regulation of mRNA stability as a novel immune therapy for various inflammatory diseases, such as arthritis and dermatitis.

UI MeSH Term Description Entries
D007108 Immune Tolerance The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc. Immunosuppression (Physiology),Immunosuppressions (Physiology),Tolerance, Immune
D003713 Dendritic Cells Specialized cells of the hematopoietic system that have branch-like extensions. They are found throughout the lymphatic system, and in non-lymphoid tissues such as SKIN and the epithelia of the intestinal, respiratory, and reproductive tracts. They trap and process ANTIGENS, and present them to T-CELLS, thereby stimulating CELL-MEDIATED IMMUNITY. They are different from the non-hematopoietic FOLLICULAR DENDRITIC CELLS, which have a similar morphology and immune system function, but with respect to humoral immunity (ANTIBODY PRODUCTION). Dendritic Cells, Interdigitating,Interdigitating Cells,Plasmacytoid Dendritic Cells,Veiled Cells,Dendritic Cells, Interstitial,Dendritic Cells, Plasmacytoid,Interdigitating Dendritic Cells,Interstitial Dendritic Cells,Cell, Dendritic,Cell, Interdigitating,Cell, Interdigitating Dendritic,Cell, Interstitial Dendritic,Cell, Plasmacytoid Dendritic,Cell, Veiled,Cells, Dendritic,Cells, Interdigitating,Cells, Interdigitating Dendritic,Cells, Interstitial Dendritic,Cells, Plasmacytoid Dendritic,Cells, Veiled,Dendritic Cell,Dendritic Cell, Interdigitating,Dendritic Cell, Interstitial,Dendritic Cell, Plasmacytoid,Interdigitating Cell,Interdigitating Dendritic Cell,Interstitial Dendritic Cell,Plasmacytoid Dendritic Cell,Veiled Cell
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012333 RNA, Messenger RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm. Messenger RNA,Messenger RNA, Polyadenylated,Poly(A) Tail,Poly(A)+ RNA,Poly(A)+ mRNA,RNA, Messenger, Polyadenylated,RNA, Polyadenylated,mRNA,mRNA, Non-Polyadenylated,mRNA, Polyadenylated,Non-Polyadenylated mRNA,Poly(A) RNA,Polyadenylated mRNA,Non Polyadenylated mRNA,Polyadenylated Messenger RNA,Polyadenylated RNA,RNA, Polyadenylated Messenger,mRNA, Non Polyadenylated
D015658 HIV Infections Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS). HTLV-III Infections,HTLV-III-LAV Infections,T-Lymphotropic Virus Type III Infections, Human,HIV Coinfection,Coinfection, HIV,Coinfections, HIV,HIV Coinfections,HIV Infection,HTLV III Infections,HTLV III LAV Infections,HTLV-III Infection,HTLV-III-LAV Infection,Infection, HIV,Infection, HTLV-III,Infection, HTLV-III-LAV,Infections, HIV,Infections, HTLV-III,Infections, HTLV-III-LAV,T Lymphotropic Virus Type III Infections, Human
D051816 Tristetraprolin A ZINC FINGER MOTIF containing transcription factor that was originally identified as one of the IMMEDIATE-EARLY PROTEINS. It shuttles between the CYTOPLASM and the CELL NUCLEUS and is involved in destabilization of mRNAs for TUMOR NECROSIS FACTOR-ALPHA. G0-G1 Switch Regulatory Protein 24,Tristetraprolin Protein,Zinc Finger Protein 36,G0 G1 Switch Regulatory Protein 24
D056704 Adaptive Immunity Protection from an infectious disease agent that is mediated by B- and T- LYMPHOCYTES following exposure to specific antigen, and characterized by IMMUNOLOGIC MEMORY. It can result from either previous infection with that agent or vaccination (IMMUNITY, ACTIVE), or transfer of antibody or lymphocytes from an immune donor (IMMUNIZATION, PASSIVE). Acquired Immunity,Hybrid Immunity,Adaptive Immune Response,Adoptive Immunity,Immunity, Adaptive,Hybrid Immunities,Immune Response, Adaptive,Immunity, Acquired,Immunity, Adoptive,Immunity, Hybrid,Response, Adaptive Immune
D017951 Antigen Presentation The process by which antigen is presented to lymphocytes in a form they can recognize. This is performed by antigen presenting cells (APCs). Some antigens require processing before they can be recognized. Antigen processing consists of ingestion and partial digestion of the antigen by the APC, followed by presentation of fragments on the cell surface. (From Rosen et al., Dictionary of Immunology, 1989) Antigen Processing,Antigen Presentations,Antigen Processings
D020871 RNA Stability The extent to which an RNA molecule retains its structural integrity and resists degradation by RNASE, and base-catalyzed HYDROLYSIS, under changing in vivo or in vitro conditions. RNA Decay,mRNA Decay,mRNA Transcript Degradation,RNA Degradation,RNA Instability,mRNA Degradation,mRNA Instability,mRNA Stability,Decay, RNA,Decay, mRNA,Degradation, RNA,Degradation, mRNA,Degradation, mRNA Transcript,Instability, RNA,Instability, mRNA,Stability, RNA,Stability, mRNA,Transcript Degradation, mRNA

Related Publications

Yiwei Zhang, and Jian Zhou, and Zhiyuan Wei, and Hui Dong, and Di Yang, and Yuanyu Deng, and Jiahui Li, and Saiyu Shi, and Yi Sun, and Huimin Lu, and Jizhao Yuan, and Bing Ni, and Yuzhang Wu, and Yi Tian, and Chao Han
January 2005, Audiology & neuro-otology,
Yiwei Zhang, and Jian Zhou, and Zhiyuan Wei, and Hui Dong, and Di Yang, and Yuanyu Deng, and Jiahui Li, and Saiyu Shi, and Yi Sun, and Huimin Lu, and Jizhao Yuan, and Bing Ni, and Yuzhang Wu, and Yi Tian, and Chao Han
April 2007, Immunity,
Yiwei Zhang, and Jian Zhou, and Zhiyuan Wei, and Hui Dong, and Di Yang, and Yuanyu Deng, and Jiahui Li, and Saiyu Shi, and Yi Sun, and Huimin Lu, and Jizhao Yuan, and Bing Ni, and Yuzhang Wu, and Yi Tian, and Chao Han
January 2021, Journal of immunology research,
Yiwei Zhang, and Jian Zhou, and Zhiyuan Wei, and Hui Dong, and Di Yang, and Yuanyu Deng, and Jiahui Li, and Saiyu Shi, and Yi Sun, and Huimin Lu, and Jizhao Yuan, and Bing Ni, and Yuzhang Wu, and Yi Tian, and Chao Han
January 2019, Frontiers in immunology,
Yiwei Zhang, and Jian Zhou, and Zhiyuan Wei, and Hui Dong, and Di Yang, and Yuanyu Deng, and Jiahui Li, and Saiyu Shi, and Yi Sun, and Huimin Lu, and Jizhao Yuan, and Bing Ni, and Yuzhang Wu, and Yi Tian, and Chao Han
January 2019, Frontiers in cellular and infection microbiology,
Yiwei Zhang, and Jian Zhou, and Zhiyuan Wei, and Hui Dong, and Di Yang, and Yuanyu Deng, and Jiahui Li, and Saiyu Shi, and Yi Sun, and Huimin Lu, and Jizhao Yuan, and Bing Ni, and Yuzhang Wu, and Yi Tian, and Chao Han
July 2013, Molecules (Basel, Switzerland),
Yiwei Zhang, and Jian Zhou, and Zhiyuan Wei, and Hui Dong, and Di Yang, and Yuanyu Deng, and Jiahui Li, and Saiyu Shi, and Yi Sun, and Huimin Lu, and Jizhao Yuan, and Bing Ni, and Yuzhang Wu, and Yi Tian, and Chao Han
May 2014, American journal of reproductive immunology (New York, N.Y. : 1989),
Yiwei Zhang, and Jian Zhou, and Zhiyuan Wei, and Hui Dong, and Di Yang, and Yuanyu Deng, and Jiahui Li, and Saiyu Shi, and Yi Sun, and Huimin Lu, and Jizhao Yuan, and Bing Ni, and Yuzhang Wu, and Yi Tian, and Chao Han
March 2015, eLife,
Yiwei Zhang, and Jian Zhou, and Zhiyuan Wei, and Hui Dong, and Di Yang, and Yuanyu Deng, and Jiahui Li, and Saiyu Shi, and Yi Sun, and Huimin Lu, and Jizhao Yuan, and Bing Ni, and Yuzhang Wu, and Yi Tian, and Chao Han
May 2015, Nature reviews. Immunology,
Yiwei Zhang, and Jian Zhou, and Zhiyuan Wei, and Hui Dong, and Di Yang, and Yuanyu Deng, and Jiahui Li, and Saiyu Shi, and Yi Sun, and Huimin Lu, and Jizhao Yuan, and Bing Ni, and Yuzhang Wu, and Yi Tian, and Chao Han
May 2024, Biomaterials,
Copied contents to your clipboard!