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Itch arising from glabrous skin (palms and soles) has attracted limited attention within the field due to the lack of methodology. This is despite glabrous itch arising from many medical conditions such as plantar and palmar psoriasis, dyshidrosis, and cholestasis. Therefore, we developed a mouse glabrous skin behavioral assay to investigate the contribution of three previously identified pruriceptive neurons in glabrous skin itch. Our results show that MrgprA3+ and MrgprD+ neurons, although key mediators for hairy skin itch, do not play important roles in glabrous skin itch, demonstrating a mechanistic difference in itch sensation between hairy and glabrous skin. We found that MrgprC11+ neurons are the major mediators for glabrous skin itch. Activation of MrgprC11+ neurons induced glabrous skin itch, while ablation of MrgprC11+ neurons reduced both acute and chronic glabrous skin itch. Our study provides insights into the mechanisms of itch and opens up new avenues for future glabrous skin itch research.
Haley R Steele, and
Yanyan Xing, and
Yuyan Zhu, and
Henry B Hilley, and
Katy Lawson, and
Yeseul Nho, and
Taylor Niehoff, and
Liang Han
September 2017,
Cell,
Haley R Steele, and
Yanyan Xing, and
Yuyan Zhu, and
Henry B Hilley, and
Katy Lawson, and
Yeseul Nho, and
Taylor Niehoff, and
Liang Han
April 2022,
The Journal of allergy and clinical immunology,
Haley R Steele, and
Yanyan Xing, and
Yuyan Zhu, and
Henry B Hilley, and
Katy Lawson, and
Yeseul Nho, and
Taylor Niehoff, and
Liang Han
September 2020,
The Journal of neuroscience : the official journal of the Society for Neuroscience,
Haley R Steele, and
Yanyan Xing, and
Yuyan Zhu, and
Henry B Hilley, and
Katy Lawson, and
Yeseul Nho, and
Taylor Niehoff, and
Liang Han
January 2014,
Nature reviews. Neuroscience,
Haley R Steele, and
Yanyan Xing, and
Yuyan Zhu, and
Henry B Hilley, and
Katy Lawson, and
Yeseul Nho, and
Taylor Niehoff, and
Liang Han
January 2022,
Proceedings of the National Academy of Sciences of the United States of America,
Haley R Steele, and
Yanyan Xing, and
Yuyan Zhu, and
Henry B Hilley, and
Katy Lawson, and
Yeseul Nho, and
Taylor Niehoff, and
Liang Han
January 1991,
European journal of morphology,
Haley R Steele, and
Yanyan Xing, and
Yuyan Zhu, and
Henry B Hilley, and
Katy Lawson, and
Yeseul Nho, and
Taylor Niehoff, and
Liang Han
January 1981,
Izvestiia Akademii nauk SSSR. Seriia biologicheskaia,
Haley R Steele, and
Yanyan Xing, and
Yuyan Zhu, and
Henry B Hilley, and
Katy Lawson, and
Yeseul Nho, and
Taylor Niehoff, and
Liang Han
November 2023,
Cell reports,
Haley R Steele, and
Yanyan Xing, and
Yuyan Zhu, and
Henry B Hilley, and
Katy Lawson, and
Yeseul Nho, and
Taylor Niehoff, and
Liang Han
June 2021,
The Journal of allergy and clinical immunology,
Haley R Steele, and
Yanyan Xing, and
Yuyan Zhu, and
Henry B Hilley, and
Katy Lawson, and
Yeseul Nho, and
Taylor Niehoff, and
Liang Han
July 2011,
Science signaling,
