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One hundred and fifty-six German, Italian and Polish patients with confirmed aspirin-induced asthma underwent open oral challenges with increasing doses of tartrazine up to 25 mg. All positive challenges were repeated under double-blind conditions. Only 4 of 156 patients (all Polish) had positive reactions in a double-blind test, as evidenced by a fall in FEV1 greater than 25% from baseline and corresponding clinical symptoms. Sixty-five patients who tolerated 25 mg tartrazine well received 50-3,000 mg tartrazine and none showed adverse reactions. Thus, intolerance to tartrazine appears to be rare among Central-European and South-European patients with aspirin-induced asthma, its frequency amounting to about 2.6%.
C Virchow, and
A Szczeklik, and
S Bianco, and
M Schmitz-Schumann, and
E Juhl, and
M Robuschi, and
C Damonte, and
G Menz, and
M Serwonska
June 1977,
Comprehensive therapy,
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A Szczeklik, and
S Bianco, and
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M Robuschi, and
C Damonte, and
G Menz, and
M Serwonska
October 1987,
Allergie et immunologie,
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G Menz, and
M Serwonska
January 1982,
Archives of dermatological research,
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M Serwonska
October 1983,
Arerugi = [Allergy],
C Virchow, and
A Szczeklik, and
S Bianco, and
M Schmitz-Schumann, and
E Juhl, and
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G Menz, and
M Serwonska
October 1978,
Allergy,
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G Menz, and
M Serwonska
February 2000,
Revue des maladies respiratoires,
C Virchow, and
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February 2002,
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego,
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M Serwonska
February 1978,
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C Virchow, and
A Szczeklik, and
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C Damonte, and
G Menz, and
M Serwonska
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M Schmitz-Schumann, and
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November 1984,
Polskie Archiwum Medycyny Wewnetrznej,
