Biomaterial Database

[Laminin P1 and procollagen III peptide in serum: activity parameters in chronic inflammatory joint diseases]. 1988

M Schneider, and J Lohmann, and U Gerlach

Medizinische Klinik und Poliklinik B, Westfälischen Wilhelms-Universität Münster.

Chronic inflammatory arthritis causes progressive destruction of the joints. Non-specific parameters of inflammation are used in controls, because specific tests are not yet available. In this study, we determined parameters of connective tissue metabolism in 215 sera of patients with chronic inflammatory arthritis, since morphological changes in synovial tissue in these diseases are characterized by proliferation of mesenchymal cells and extracellular matrix. Serum concentration of procollagen-III-peptide (P-III-P) was increased in patients with a markedly progressive disease. Fragment P1 of the basement membrane component laminin was found to be enhanced in the serum of all groups of patients - even in the early stages of diseases. In addition, follow-up over 2 years showed a good correlation between the progression of the diseases and the serum concentration of the two parameters. Our results indicate that P-III-P and laminin P1 serum content specifically reflect the proliferation of mesenchymal tissue in rheumatic diseases of the joints. Determination of both parameters may therefore be useful in estimating the progression of the disease and the benefit of treatment.

UI	MeSH Term	Description	Entries
D007797	Laminin	Large, noncollagenous glycoprotein with antigenic properties. It is localized in the basement membrane lamina lucida and functions to bind epithelial cells to the basement membrane. Evidence suggests that the protein plays a role in tumor invasion.	Merosin,Glycoprotein GP-2,Laminin M,Laminin M Chain,Chain, Laminin M,Glycoprotein GP 2,M Chain, Laminin
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D010446	Peptide Fragments	Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.	Peptide Fragment,Fragment, Peptide,Fragments, Peptide
D011347	Procollagen	A biosynthetic precursor of collagen containing additional amino acid sequences at the amino-terminal and carboxyl-terminal ends of the polypeptide chains.	Protocollagen,Procollagen Type M
D011379	Prognosis	A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.	Prognostic Factor,Prognostic Factors,Factor, Prognostic,Factors, Prognostic,Prognoses
D011565	Psoriasis	A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis.	Palmoplantaris Pustulosis,Pustular Psoriasis of Palms and Soles,Pustulosis Palmaris et Plantaris,Pustulosis of Palms and Soles,Psoriases
D002648	Child	A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.	Children
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293	Adolescent	A person 13 to 18 years of age.	Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults