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A patient with biopsy-proven spindle cell carcinoma, of unknown primary site, metastatic to the neck and to the lung, was treated with chemotherapy consisting of cisplatin (20 mg/m2/day) on days 1-5 and 5-fluorouracil (1000 mg/m2/day) on days 1-5. The regimen was repeated every 28 days. The patient had a complete response confirmed by computerized tomography. The patient is in a disease-free status 12 months after diagnosis. Toxicity was mild. To our knowledge, this case represents the first chemotherapy induced complete response documented in this rare entity.
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