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Introduction of ORF3a-Q57H SARS-CoV-2 Variant Causing Fourth Epidemic Wave of COVID-19, Hong Kong, China. 2021
Daniel K W Chu, and
Kenrie P Y Hui, and
Haogao Gu, and
Ronald L W Ko, and
Pavithra Krishnan, and
Daisy Y M Ng, and
Gigi Y Z Liu, and
Carrie K C Wan, and
Man-Chun Cheung, and
Ka-Chun Ng, and
John M Nicholls, and
Dominic N C Tsang, and
Malik Peiris, and
Michael C W Chan, and
Leo L M Poon
We describe an introduction of clade GH severe acute respiratory syndrome coronavirus 2 causing a fourth wave of coronavirus disease in Hong Kong. The virus has an ORF3a-Q57H mutation, causing truncation of ORF3b. This virus evades induction of cytokine, chemokine, and interferon-stimulated gene expression in primary human respiratory cells.
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