Substantia nigra pars reticulata modulates spontaneous and goal-directed behaviour of rat. 1988

T Barth, and F Klingberg
Paul Flechsig Institute for Brain Research, Department of Neurophysiology, Karl Marx University, Leipzig, GDR.

Spontaneous and active avoidance behaviour was compared pre- and postoperatively on 11 six month old male hooded rats of the Long-Evans strain. Seven of them with small bilateral symmetric lesions only in the ventromedial part of substantia nigra pars reticulata (SNR) were characterized by a strong decrease of exploratory parameters except rearings, without differences of ambulatory activity in the open field (OF) test. The SNR group showed a significant retention loss, increased reaction times and run durations in three variants of preoperatively consolidated Y-maze performance and weakened brightness discrimination. They were unable to relearn the tasks and to reduce errors to the preoperative level which was zero. Postoperative acquisition of a new active avoidance stereotype in the jump test box was impossible. They ignored the hanging rod in this box and did not find the escape possibility. Prevailing flexor tonus of trunk and forelegs after SNR lesions was no sufficient reason for these changes, because inborn and automated programs were far less concerned than learnt or operative programs and the accuracy of goal-directed behaviour.

UI MeSH Term Description Entries
D008297 Male Males
D004924 Escape Reaction Innate response elicited by sensory stimuli associated with a threatening situation, or actual confrontation with an enemy. Flight Reaction,Escape Reactions,Flight Reactions,Reaction, Escape,Reaction, Flight,Reactions, Escape,Reactions, Flight
D005106 Exploratory Behavior The tendency to explore or investigate a novel environment. It is considered a motivation not clearly distinguishable from curiosity. Curiosity,Novelty-Seeking Behavior,Behavior, Exploratory,Behavior, Novelty-Seeking,Behaviors, Exploratory,Behaviors, Novelty-Seeking,Curiosities,Exploratory Behaviors,Novelty Seeking Behavior,Novelty-Seeking Behaviors
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001362 Avoidance Learning A response to a cue that is instrumental in avoiding a noxious experience. Aversion Behavior,Aversion Learning,Aversive Behavior,Aversive Learning,Avoidance Behavior,Aversion Behaviors,Aversive Behaviors,Avoidance Behaviors,Behavior, Aversion,Behavior, Aversive,Behavior, Avoidance,Behaviors, Aversion,Behaviors, Aversive,Behaviors, Avoidance,Learning, Aversion,Learning, Aversive,Learning, Avoidance
D001522 Behavior, Animal The observable response an animal makes to any situation. Autotomy Animal,Animal Behavior,Animal Behaviors
D013378 Substantia Nigra The black substance in the ventral midbrain or the nucleus of cells containing the black substance. These cells produce DOPAMINE, an important neurotransmitter in regulation of the sensorimotor system and mood. The dark colored MELANIN is a by-product of dopamine synthesis. Nigra, Substantia,Nigras, Substantia,Substantia Nigras
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

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