New phenolic glycosides from Anemone chinensis Bunge and their antioxidant activity. 2022

Zeng-Guang Zhang, and Yuan-Yuan Li, and Bin Lin, and Pei-Pei Guan, and Yu Mu, and Wen-Jun Qiao, and Jing-Sheng Zhang, and Xue-Shi Huang, and Li Han
Institute of Microbial Pharmaceuticals, College of Life and Health Sciences, Northeastern University, Shenyang, People's Republic of China.

ABATRACTNine compounds, five phenolic glycosides (1, 2, 4-6), three phenylpropanoids (7-9), and a furanone glycoside (3), were isolated from aqueous soluble extract of the dried roots of Anemone chinensis Bunge. The structures of new compounds (1-4) were elucidated by comprehensive spectroscopic data analysis as well as chemical evidence. Pulsatillanin A (1) demonstrated significant antioxidant effects through scavenging free radical in DPPH assay, and relieved the oxidative stress in LPS-induced RAW 264.7 cells by reducing ROS production, enhancing antioxidant enzyme SOD activity, replenishing depleted GSH in a dose-dependent manner. Western blot analysis revealed that 1 showed antioxidant activity via activating Nrf2 signaling pathway.[Formula: see text].

UI MeSH Term Description Entries
D008070 Lipopolysaccharides Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed) Lipopolysaccharide,Lipoglycans
D010636 Phenols Benzene derivatives that include one or more hydroxyl groups attached to the ring structure.
D010936 Plant Extracts Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard. Herbal Medicines,Plant Extract,Extract, Plant,Extracts, Plant,Medicines, Herbal
D006027 Glycosides Any compound that contains a constituent sugar, in which the hydroxyl group attached to the first carbon is substituted by an alcoholic, phenolic, or other group. They are named specifically for the sugar contained, such as glucoside (glucose), pentoside (pentose), fructoside (fructose), etc. Upon hydrolysis, a sugar and nonsugar component (aglycone) are formed. (From Dorland, 28th ed; From Miall's Dictionary of Chemistry, 5th ed) Glycoside
D000975 Antioxidants Naturally occurring or synthetic substances that inhibit or retard oxidation reactions. They counteract the damaging effects of oxidation in animal tissues. Anti-Oxidant,Antioxidant,Antioxidant Activity,Endogenous Antioxidant,Endogenous Antioxidants,Anti-Oxidant Effect,Anti-Oxidant Effects,Anti-Oxidants,Antioxidant Effect,Antioxidant Effects,Activity, Antioxidant,Anti Oxidant,Anti Oxidant Effect,Anti Oxidant Effects,Anti Oxidants,Antioxidant, Endogenous,Antioxidants, Endogenous
D013482 Superoxide Dismutase An oxidoreductase that catalyzes the reaction between SUPEROXIDES and hydrogen to yield molecular oxygen and hydrogen peroxide. The enzyme protects the cell against dangerous levels of superoxide. Hemocuprein,Ag-Zn Superoxide Dismutase,Cobalt Superoxide Dismutase,Cu-Superoxide Dismutase,Erythrocuprein,Fe-Superoxide Dismutase,Fe-Zn Superoxide Dismutase,Iron Superoxide Dismutase,Manganese Superoxide Dismutase,Mn-SOD,Mn-Superoxide Dismutase,Ag Zn Superoxide Dismutase,Cu Superoxide Dismutase,Dismutase, Ag-Zn Superoxide,Dismutase, Cobalt Superoxide,Dismutase, Cu-Superoxide,Dismutase, Fe-Superoxide,Dismutase, Fe-Zn Superoxide,Dismutase, Iron Superoxide,Dismutase, Manganese Superoxide,Dismutase, Mn-Superoxide,Dismutase, Superoxide,Fe Superoxide Dismutase,Fe Zn Superoxide Dismutase,Mn SOD,Mn Superoxide Dismutase,Superoxide Dismutase, Ag-Zn,Superoxide Dismutase, Cobalt,Superoxide Dismutase, Fe-Zn,Superoxide Dismutase, Iron,Superoxide Dismutase, Manganese
D017382 Reactive Oxygen Species Molecules or ions formed by the incomplete one-electron reduction of oxygen. These reactive oxygen intermediates include SINGLET OXYGEN; SUPEROXIDES; PEROXIDES; HYDROXYL RADICAL; and HYPOCHLOROUS ACID. They contribute to the microbicidal activity of PHAGOCYTES, regulation of SIGNAL TRANSDUCTION and GENE EXPRESSION, and the oxidative damage to NUCLEIC ACIDS; PROTEINS; and LIPIDS. Active Oxygen Species,Oxygen Radical,Oxygen Radicals,Pro-Oxidant,Reactive Oxygen Intermediates,Active Oxygen,Oxygen Species, Reactive,Pro-Oxidants,Oxygen, Active,Pro Oxidant,Pro Oxidants,Radical, Oxygen
D051267 NF-E2-Related Factor 2 A basic-leucine zipper transcription factor that was originally described as a transcriptional regulator controlling expression of the BETA-GLOBIN gene. It may regulate the expression of a wide variety of genes that play a role in protecting cells from oxidative damage. Nfe2l2 Protein,Nuclear Factor (Erythroid-Derived 2)-Like 2 Protein,Nuclear Factor E2-Related Factor 2,NF E2 Related Factor 2,Nuclear Factor E2 Related Factor 2
D031883 Anemone A plant genus of the family RANUNCULACEAE that contains triterpene saponins. The root of Anemone raddeana is the source of a Chinese folk medicine, zhu jie xian fu. The common name of liverwort is also used with other plants. This genus is unrelated to SEA ANEMONES. Anemone hepatica,Anemone raddeana,Anemone hepaticas,Anemone raddeanas,Anemones,hepaticas, Anemone,raddeana, Anemone

Related Publications

Zeng-Guang Zhang, and Yuan-Yuan Li, and Bin Lin, and Pei-Pei Guan, and Yu Mu, and Wen-Jun Qiao, and Jing-Sheng Zhang, and Xue-Shi Huang, and Li Han
December 2009, Natural product communications,
Zeng-Guang Zhang, and Yuan-Yuan Li, and Bin Lin, and Pei-Pei Guan, and Yu Mu, and Wen-Jun Qiao, and Jing-Sheng Zhang, and Xue-Shi Huang, and Li Han
April 2023, Molecules (Basel, Switzerland),
Zeng-Guang Zhang, and Yuan-Yuan Li, and Bin Lin, and Pei-Pei Guan, and Yu Mu, and Wen-Jun Qiao, and Jing-Sheng Zhang, and Xue-Shi Huang, and Li Han
March 2022, Food & function,
Zeng-Guang Zhang, and Yuan-Yuan Li, and Bin Lin, and Pei-Pei Guan, and Yu Mu, and Wen-Jun Qiao, and Jing-Sheng Zhang, and Xue-Shi Huang, and Li Han
February 2006, Chemistry & biodiversity,
Zeng-Guang Zhang, and Yuan-Yuan Li, and Bin Lin, and Pei-Pei Guan, and Yu Mu, and Wen-Jun Qiao, and Jing-Sheng Zhang, and Xue-Shi Huang, and Li Han
November 2021, Bioorganic chemistry,
Zeng-Guang Zhang, and Yuan-Yuan Li, and Bin Lin, and Pei-Pei Guan, and Yu Mu, and Wen-Jun Qiao, and Jing-Sheng Zhang, and Xue-Shi Huang, and Li Han
July 2022, Natural product research,
Zeng-Guang Zhang, and Yuan-Yuan Li, and Bin Lin, and Pei-Pei Guan, and Yu Mu, and Wen-Jun Qiao, and Jing-Sheng Zhang, and Xue-Shi Huang, and Li Han
March 2010, Planta medica,
Zeng-Guang Zhang, and Yuan-Yuan Li, and Bin Lin, and Pei-Pei Guan, and Yu Mu, and Wen-Jun Qiao, and Jing-Sheng Zhang, and Xue-Shi Huang, and Li Han
April 2005, Journal of natural products,
Zeng-Guang Zhang, and Yuan-Yuan Li, and Bin Lin, and Pei-Pei Guan, and Yu Mu, and Wen-Jun Qiao, and Jing-Sheng Zhang, and Xue-Shi Huang, and Li Han
November 2023, Phytochemistry,
Zeng-Guang Zhang, and Yuan-Yuan Li, and Bin Lin, and Pei-Pei Guan, and Yu Mu, and Wen-Jun Qiao, and Jing-Sheng Zhang, and Xue-Shi Huang, and Li Han
October 2010, Molecules (Basel, Switzerland),
Copied contents to your clipboard!