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Disturbances in the metabolism of purines and pyrimidines in neurologically affected patients can be reflected by aberrant concentrations of nucleosides and nucleobases in cerebrospinal fluid (CSF). However, normal values, especially for children at different ages, are lacking. We collected 1000 specimens of CSF from subjects ranging in age from newborn to 18 years, who were undergoing a diagnostic lumbar puncture for several clinical indications. Of these, 78 samples could be used retrospectively as a reference according to our criteria. The analyses were performed with a modified HPLC procedure. None of the substances shows age-dependency except uridine and uric acid. Uridine increases with age, and uric acid increases with age in boys older than 12 years.
G P Gerrits, and
A A Haagen, and
R A De Abreu, and
L A Monnens, and
F J Gabreëls, and
F J Trijbels, and
A L Theeuwes, and
J M van Baal
January 1987,
Annales de biologie clinique,
G P Gerrits, and
A A Haagen, and
R A De Abreu, and
L A Monnens, and
F J Gabreëls, and
F J Trijbels, and
A L Theeuwes, and
J M van Baal
April 1980,
Clinical chemistry,
G P Gerrits, and
A A Haagen, and
R A De Abreu, and
L A Monnens, and
F J Gabreëls, and
F J Trijbels, and
A L Theeuwes, and
J M van Baal
December 1978,
Acta neurologica Scandinavica,
G P Gerrits, and
A A Haagen, and
R A De Abreu, and
L A Monnens, and
F J Gabreëls, and
F J Trijbels, and
A L Theeuwes, and
J M van Baal
October 2019,
Medicine,
G P Gerrits, and
A A Haagen, and
R A De Abreu, and
L A Monnens, and
F J Gabreëls, and
F J Trijbels, and
A L Theeuwes, and
J M van Baal
August 1977,
American journal of veterinary research,
G P Gerrits, and
A A Haagen, and
R A De Abreu, and
L A Monnens, and
F J Gabreëls, and
F J Trijbels, and
A L Theeuwes, and
J M van Baal
March 2018,
Pediatrics,
G P Gerrits, and
A A Haagen, and
R A De Abreu, and
L A Monnens, and
F J Gabreëls, and
F J Trijbels, and
A L Theeuwes, and
J M van Baal
November 2015,
Clinical chemistry and laboratory medicine,
G P Gerrits, and
A A Haagen, and
R A De Abreu, and
L A Monnens, and
F J Gabreëls, and
F J Trijbels, and
A L Theeuwes, and
J M van Baal
October 1978,
Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie,
G P Gerrits, and
A A Haagen, and
R A De Abreu, and
L A Monnens, and
F J Gabreëls, and
F J Trijbels, and
A L Theeuwes, and
J M van Baal
February 2009,
Zhonghua yi xue za zhi,
G P Gerrits, and
A A Haagen, and
R A De Abreu, and
L A Monnens, and
F J Gabreëls, and
F J Trijbels, and
A L Theeuwes, and
J M van Baal
April 1988,
Annals of neurology,
