A 6-month-old crossbred calf was examined as representative of a herd of calves experiencing dyspnea and death, with few other clinical signs of illness. Physical examination of the calf identified pleural and peritoneal effusion and poor body condition. The calf did not respond to supportive treatment, and necropsy of it and another calf from the herd identified congestive heart failure as the cause of death. Gossypol toxicosis was the cause of congestive heart failure in this herd; the source of the toxin was a cottonseed meal and cottonseed hull ration fed by the owner.