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Hepatitis B is a major co-infection among people with HIV (PWHIV) worldwide. There is a paucity of data on HBV genetic diversity in India, which would be useful for targeted preventive and management interventions. To characterize the distribution of HBV genotypes and sub-genotypes, samples of 180 HIV-HBV co-infected individuals from a study previously conducted to estimate the prevalence of HBV co-infection were analyzed. Nested PCR using type-specific primers was used to identify the various HBV genotypes. Partial HBV S sequences were generated for a subset of samples using Sanger sequencing. Mutation analysis was done using the online HBVseq program. PCR based genotyping documented D (69.4 %) and A (5.6 %) to be the major genotypes in the study population. Infection with multiple genotypes was observed in 25 % co-infected individuals. D2, D5, A2, and A1 were the sub-genotypes detected. Mutations 184K and 173L were identified. HBV genotypes/ sub-genotypes play a pivotal role in the clinical outcome of chronic hepatitis B (CHB). Therefore, monitoring of CHB cases is needed to track disease progression, including early detection of hepatocellular carcinoma.
S Panicker, and
C P Girish Kumar, and
V Selvaraj, and
R Prabu, and
C Chandrasekar, and
A S Valan, and
J Suria Kumar, and
K Raja
November 2011,
Indian journal of medical sciences,
S Panicker, and
C P Girish Kumar, and
V Selvaraj, and
R Prabu, and
C Chandrasekar, and
A S Valan, and
J Suria Kumar, and
K Raja
December 2007,
The Journal of infection,
S Panicker, and
C P Girish Kumar, and
V Selvaraj, and
R Prabu, and
C Chandrasekar, and
A S Valan, and
J Suria Kumar, and
K Raja
May 2008,
The Indian journal of medical research,
S Panicker, and
C P Girish Kumar, and
V Selvaraj, and
R Prabu, and
C Chandrasekar, and
A S Valan, and
J Suria Kumar, and
K Raja
April 2010,
Indian journal of medical sciences,
S Panicker, and
C P Girish Kumar, and
V Selvaraj, and
R Prabu, and
C Chandrasekar, and
A S Valan, and
J Suria Kumar, and
K Raja
January 2017,
Journal of the International Association of Providers of AIDS Care,
S Panicker, and
C P Girish Kumar, and
V Selvaraj, and
R Prabu, and
C Chandrasekar, and
A S Valan, and
J Suria Kumar, and
K Raja
January 2014,
PloS one,
S Panicker, and
C P Girish Kumar, and
V Selvaraj, and
R Prabu, and
C Chandrasekar, and
A S Valan, and
J Suria Kumar, and
K Raja
April 2005,
The Indian journal of medical research,
S Panicker, and
C P Girish Kumar, and
V Selvaraj, and
R Prabu, and
C Chandrasekar, and
A S Valan, and
J Suria Kumar, and
K Raja
November 2008,
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases,
S Panicker, and
C P Girish Kumar, and
V Selvaraj, and
R Prabu, and
C Chandrasekar, and
A S Valan, and
J Suria Kumar, and
K Raja
January 2019,
Indian journal of medical microbiology,
S Panicker, and
C P Girish Kumar, and
V Selvaraj, and
R Prabu, and
C Chandrasekar, and
A S Valan, and
J Suria Kumar, and
K Raja
March 2009,
AIDS research and human retroviruses,
