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Alzheimer's disease (AD) brain trace-element imbalances in the amygdala, hippocampus and nucleus basalis of Meynert (nbM) are found in most cases to be consistent with those previously reported in samples derived principally from AD cerebral cortex (Ehmann et al., 1986). The elevation of mercury in AD nbM, as compared to age-matched controls, is the largest trace-element imbalance observed to date in AD brain. In addition to the general confirmation of imbalances for Cs, Hg, N, Na, P, and Rb noted previously in cerebral cortex samples, imbalances for Fe, K, Sc, and Zn were observed in two regions and one region also exhibited imbalances for both Co and Se. Persistent imbalances for the univalent cations Na, K, Rb and Cs support arguments for a membrane abnormality in AD. The data presented here also provide the first comprehensive simultaneous multi-element determinations in both control and AD nbM.
C M Thompson, and
W R Markesbery, and
W D Ehmann, and
Y X Mao, and
D E Vance
July 2021,
Clinical anatomy (New York, N.Y.),
C M Thompson, and
W R Markesbery, and
W D Ehmann, and
Y X Mao, and
D E Vance
January 1986,
Neurotoxicology,
C M Thompson, and
W R Markesbery, and
W D Ehmann, and
Y X Mao, and
D E Vance
January 1950,
Proceedings of the Royal Society of London. Series B, Biological sciences,
C M Thompson, and
W R Markesbery, and
W D Ehmann, and
Y X Mao, and
D E Vance
November 1990,
Brain research,
C M Thompson, and
W R Markesbery, and
W D Ehmann, and
Y X Mao, and
D E Vance
January 1988,
Neurotoxicology,
C M Thompson, and
W R Markesbery, and
W D Ehmann, and
Y X Mao, and
D E Vance
January 1991,
Neurologia croatica : glasilo Udruzenja neurologa Jugoslavije = official journal of Yugoslav Neurological Association,
C M Thompson, and
W R Markesbery, and
W D Ehmann, and
Y X Mao, and
D E Vance
January 1984,
Neurobiology of aging,
C M Thompson, and
W R Markesbery, and
W D Ehmann, and
Y X Mao, and
D E Vance
October 1948,
Nucleonics,
C M Thompson, and
W R Markesbery, and
W D Ehmann, and
Y X Mao, and
D E Vance
November 1948,
Nucleonics,
C M Thompson, and
W R Markesbery, and
W D Ehmann, and
Y X Mao, and
D E Vance
September 1948,
Nucleonics,
