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Complex formation between beta-cyclodextrin and six antimycotic imidazole derivatives has been studied. The solubility of all drugs was increased in the presence of beta-cyclodextrin. The smallest increase (approx. 5-fold) was observed for miconazol, and the largest increase (approx. 160-fold) was observed for bifonazol. Apparent 1:1-complex constants were measured and found to decrease in the order: bifonazol greater than ketoconazol greater than tioconazol greater than miconazol greater than itraconazol greater than clotrimazol. The complexes appeared to possess a low, if any, antimicrobial activity. Measurement of inhibition zone sizes, with four test organisms was used to study the release of the antimycotic drugs from topical preparations. The antimycotic drugs were more readily released from topical preparations containing beta-cyclodextrin than from the same vehicles without beta-cyclodextrin. The rationale of beta-cyclodextrin addition to antimycotic topical preparations is discussed.
H Van Doorne, and
E H Bosch, and
C F Lerk
January 1978,
Mykosen. Supplement,
H Van Doorne, and
E H Bosch, and
C F Lerk
August 1971,
Biochemical pharmacology,
H Van Doorne, and
E H Bosch, and
C F Lerk
June 1964,
The Journal of pharmacy and pharmacology,
H Van Doorne, and
E H Bosch, and
C F Lerk
March 1983,
Fortschritte der Medizin,
H Van Doorne, and
E H Bosch, and
C F Lerk
November 1993,
Journal of inorganic biochemistry,
H Van Doorne, and
E H Bosch, and
C F Lerk
January 2009,
Molecules (Basel, Switzerland),
H Van Doorne, and
E H Bosch, and
C F Lerk
April 1968,
Biochimica et biophysica acta,
H Van Doorne, and
E H Bosch, and
C F Lerk
April 2006,
Inorganic chemistry,
H Van Doorne, and
E H Bosch, and
C F Lerk
August 2011,
European journal of medicinal chemistry,
H Van Doorne, and
E H Bosch, and
C F Lerk
October 2011,
Bulletin of experimental biology and medicine,
