BIOMAT Database Logo BIOMAT Database Logo

Myeloid-derived suppressor cell subtypes differentially influence T-cell function, T-helper subset differentiation, and clinical course in CLL. 2021

Gerardo Ferrer, and Byeongho Jung, and Pui Yan Chiu, and Rukhsana Aslam, and Florencia Palacios, and Andrea Nicola Mazzarello, and Stefano Vergani, and Davide Bagnara, and Shih-Shih Chen, and Sophia Yancopoulos, and Aliki Xochelli, and Xiao-Jie Yan, and Jan A Burger, and Jacqueline C Barrientos, and Jonathan E Kolitz, and Steven L Allen, and Kostas Stamatopoulos, and Kanti R Rai, and Barbara Sherry, and Nicholas Chiorazzi
Karches Center for Oncology Research, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.

Cancer pathogenesis involves the interplay of tumor- and microenvironment-derived stimuli. Here we focused on the influence of an immunomodulatory cell type, myeloid-derived suppressor cells (MDSCs), and their lineage-related subtypes on autologous T lymphocytes. Although MDSCs as a group correlated with an immunosuppressive Th repertoire and worse clinical course, MDSC subtypes (polymorphonuclear, PMN-MDSC, and monocytic, M-MDSCs) were often functionally discordant. In vivo, PMN-MDSCs existed in higher numbers, correlated with different Th-subsets, and more strongly associated with poor clinical course than M-MDSCs. In vitro, PMN-MDSCs were more efficient at blocking T-cell growth and promoted Th17 differentiation. Conversely, in vitro M-MDSCs varied in their ability to suppress T-cell proliferation, due to the action of TNFα, and promoted a more immunostimulatory Th compartment. Ibrutinib therapy impacted MDSCs differentially as well, since after initiating therapy, PMN-MDSC numbers progressively declined, whereas M-MDSC numbers were unaffected, leading to a set of less immunosuppressive Th cells. Consistent with this, clinical improvement based on decreasing CLL-cell numbers correlated with the decrease in PMN-MDSCs. Collectively, the data support a balance between PMN-MDSC and M-MDSC numbers and function influencing CLL disease course.

UI MeSH Term Description Entries
D008213 Lymphocyte Activation Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION. Blast Transformation,Blastogenesis,Lymphoblast Transformation,Lymphocyte Stimulation,Lymphocyte Transformation,Transformation, Blast,Transformation, Lymphoblast,Transformation, Lymphocyte,Activation, Lymphocyte,Stimulation, Lymphocyte
D008297 Male Males
D009000 Monocytes Large, phagocytic mononuclear leukocytes produced in the vertebrate BONE MARROW and released into the BLOOD; contain a large, oval or somewhat indented nucleus surrounded by voluminous cytoplasm and numerous organelles. Monocyte
D002454 Cell Differentiation Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs. Differentiation, Cell,Cell Differentiations,Differentiations, Cell
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000072737 Myeloid-Derived Suppressor Cells A heterogeneous, immature population of myeloid cells that can suppress the activity of T-CELLS and NATURAL KILLER CELLS in the INNATE IMMUNE RESPONSE and ADAPTIVE IMMUNE RESPONSE. They play important roles in ONCOGENESIS; INFLAMMATION; and INFECTION. MDSC,Myeloid Derived Suppressor Cell,MDSCs,Cell, Myeloid-Derived Suppressor,Cells, Myeloid-Derived Suppressor,Myeloid Derived Suppressor Cells,Myeloid-Derived Suppressor Cell,Suppressor Cell, Myeloid-Derived,Suppressor Cells, Myeloid-Derived
D013601 T-Lymphocytes Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen. T Cell,T Lymphocyte,T-Cells,Thymus-Dependent Lymphocytes,Cell, T,Cells, T,Lymphocyte, T,Lymphocyte, Thymus-Dependent,Lymphocytes, T,Lymphocytes, Thymus-Dependent,T Cells,T Lymphocytes,T-Cell,T-Lymphocyte,Thymus Dependent Lymphocytes,Thymus-Dependent Lymphocyte
D015451 Leukemia, Lymphocytic, Chronic, B-Cell A chronic leukemia characterized by abnormal B-lymphocytes and often generalized lymphadenopathy. In patients presenting predominately with blood and bone marrow involvement it is called chronic lymphocytic leukemia (CLL); in those predominately with enlarged lymph nodes it is called small lymphocytic lymphoma. These terms represent spectrums of the same disease. B-Cell Leukemia, Chronic,B-Lymphocytic Leukemia, Chronic,Chronic Lymphocytic Leukemia,Leukemia, B-Cell, Chronic,Leukemia, Lymphocytic, Chronic,Lymphocytic Leukemia, Chronic, B-Cell,Lymphoma, Small Lymphocytic,B-Cell Chronic Lymphocytic Leukemia,B-Cell Malignancy, Low-Grade,Diffuse Well-Differentiated Lymphocytic Lymphoma,Disrupted In B-Cell Malignancy,Leukemia, B Cell, Chronic,Leukemia, Chronic Lymphatic,Leukemia, Chronic Lymphocytic,Leukemia, Chronic Lymphocytic, B-Cell,Leukemia, Lymphoblastic, Chronic,Leukemia, Lymphocytic, Chronic, B Cell,Lymphoblastic Leukemia, Chronic,Lymphocytic Leukemia, Chronic,Lymphocytic Leukemia, Chronic, B Cell,Lymphocytic Lymphoma,Lymphocytic Lymphoma, Diffuse, Well Differentiated,Lymphocytic Lymphoma, Diffuse, Well-Differentiated,Lymphocytic Lymphoma, Well Differentiated,Lymphocytic Lymphoma, Well-Differentiated,Lymphoma, Lymphocytic,Lymphoma, Lymphocytic, Diffuse, Well Differentiated,Lymphoma, Lymphocytic, Diffuse, Well-Differentiated,Lymphoma, Lymphocytic, Well Differentiated,Lymphoma, Lymphocytic, Well-Differentiated,Lymphoma, Lymphoplasmacytoid, CLL,Lymphoma, Small Lymphocytic, Plasmacytoid,Lymphoma, Small-Cell,Lymphoplasmacytoid Lymphoma, CLL,Small-Cell Lymphoma,B Cell Chronic Lymphocytic Leukemia,B Cell Leukemia, Chronic,B Cell Malignancy, Low Grade,B Lymphocytic Leukemia, Chronic,B-Cell Leukemias, Chronic,B-Cell Malignancies, Low-Grade,B-Lymphocytic Leukemias, Chronic,CLL Lymphoplasmacytoid Lymphoma,CLL Lymphoplasmacytoid Lymphomas,Chronic B-Cell Leukemia,Chronic B-Cell Leukemias,Chronic B-Lymphocytic Leukemia,Chronic B-Lymphocytic Leukemias,Chronic Lymphatic Leukemia,Chronic Lymphatic Leukemias,Chronic Lymphoblastic Leukemia,Chronic Lymphoblastic Leukemias,Chronic Lymphocytic Leukemias,Diffuse Well Differentiated Lymphocytic Lymphoma,Disrupted In B Cell Malignancy,Leukemia, Chronic B-Cell,Leukemia, Chronic B-Lymphocytic,Leukemias, Chronic B-Cell,Leukemias, Chronic B-Lymphocytic,Leukemias, Chronic Lymphatic,Leukemias, Chronic Lymphoblastic,Low-Grade B-Cell Malignancies,Low-Grade B-Cell Malignancy,Lymphatic Leukemia, Chronic,Lymphatic Leukemias, Chronic,Lymphoblastic Leukemias, Chronic,Lymphocytic Leukemias, Chronic,Lymphocytic Lymphoma, Small,Lymphocytic Lymphomas,Lymphocytic Lymphomas, Small,Lymphocytic Lymphomas, Well-Differentiated,Lymphoma, CLL Lymphoplasmacytoid,Lymphoma, Small Cell,Lymphoma, Well-Differentiated Lymphocytic,Lymphomas, CLL Lymphoplasmacytoid,Lymphomas, Lymphocytic,Lymphomas, Small Lymphocytic,Lymphomas, Small-Cell,Lymphomas, Well-Differentiated Lymphocytic,Lymphoplasmacytoid Lymphomas, CLL,Malignancies, Low-Grade B-Cell,Malignancy, Low-Grade B-Cell,Small Cell Lymphoma,Small Lymphocytic Lymphoma,Small Lymphocytic Lymphomas,Small-Cell Lymphomas,Well-Differentiated Lymphocytic Lymphoma,Well-Differentiated Lymphocytic Lymphomas
D016022 Case-Control Studies Comparisons that start with the identification of persons with the disease or outcome of interest and a control (comparison, referent) group without the disease or outcome of interest. The relationship of an attribute is examined by comparing both groups with regard to the frequency or levels of outcome over time. Case-Base Studies,Case-Comparison Studies,Case-Referent Studies,Matched Case-Control Studies,Nested Case-Control Studies,Case Control Studies,Case-Compeer Studies,Case-Referrent Studies,Case Base Studies,Case Comparison Studies,Case Control Study,Case Referent Studies,Case Referrent Studies,Case-Comparison Study,Case-Control Studies, Matched,Case-Control Studies, Nested,Case-Control Study,Case-Control Study, Matched,Case-Control Study, Nested,Case-Referent Study,Case-Referrent Study,Matched Case Control Studies,Matched Case-Control Study,Nested Case Control Studies,Nested Case-Control Study,Studies, Case Control,Studies, Case-Base,Studies, Case-Comparison,Studies, Case-Compeer,Studies, Case-Control,Studies, Case-Referent,Studies, Case-Referrent,Studies, Matched Case-Control,Studies, Nested Case-Control,Study, Case Control,Study, Case-Comparison,Study, Case-Control,Study, Case-Referent,Study, Case-Referrent,Study, Matched Case-Control,Study, Nested Case-Control

Related Publications

Gerardo Ferrer, and Byeongho Jung, and Pui Yan Chiu, and Rukhsana Aslam, and Florencia Palacios, and Andrea Nicola Mazzarello, and Stefano Vergani, and Davide Bagnara, and Shih-Shih Chen, and Sophia Yancopoulos, and Aliki Xochelli, and Xiao-Jie Yan, and Jan A Burger, and Jacqueline C Barrientos, and Jonathan E Kolitz, and Steven L Allen, and Kostas Stamatopoulos, and Kanti R Rai, and Barbara Sherry, and Nicholas Chiorazzi
Myeloid-derived suppressor cell heterogeneity and subset definition.
April 2010, Current opinion in immunology,
Gerardo Ferrer, and Byeongho Jung, and Pui Yan Chiu, and Rukhsana Aslam, and Florencia Palacios, and Andrea Nicola Mazzarello, and Stefano Vergani, and Davide Bagnara, and Shih-Shih Chen, and Sophia Yancopoulos, and Aliki Xochelli, and Xiao-Jie Yan, and Jan A Burger, and Jacqueline C Barrientos, and Jonathan E Kolitz, and Steven L Allen, and Kostas Stamatopoulos, and Kanti R Rai, and Barbara Sherry, and Nicholas Chiorazzi
Azithromycin Differentially Alters TCR-Activated Helper T Cell Subset Phenotype and Effector Function.
January 2020, Frontiers in immunology,
Gerardo Ferrer, and Byeongho Jung, and Pui Yan Chiu, and Rukhsana Aslam, and Florencia Palacios, and Andrea Nicola Mazzarello, and Stefano Vergani, and Davide Bagnara, and Shih-Shih Chen, and Sophia Yancopoulos, and Aliki Xochelli, and Xiao-Jie Yan, and Jan A Burger, and Jacqueline C Barrientos, and Jonathan E Kolitz, and Steven L Allen, and Kostas Stamatopoulos, and Kanti R Rai, and Barbara Sherry, and Nicholas Chiorazzi
Molecular mechanisms regulating myeloid-derived suppressor cell differentiation and function.
January 2011, Trends in immunology,
Gerardo Ferrer, and Byeongho Jung, and Pui Yan Chiu, and Rukhsana Aslam, and Florencia Palacios, and Andrea Nicola Mazzarello, and Stefano Vergani, and Davide Bagnara, and Shih-Shih Chen, and Sophia Yancopoulos, and Aliki Xochelli, and Xiao-Jie Yan, and Jan A Burger, and Jacqueline C Barrientos, and Jonathan E Kolitz, and Steven L Allen, and Kostas Stamatopoulos, and Kanti R Rai, and Barbara Sherry, and Nicholas Chiorazzi
Signals that influence T follicular helper cell differentiation and function.
June 2010, Seminars in immunopathology,
Gerardo Ferrer, and Byeongho Jung, and Pui Yan Chiu, and Rukhsana Aslam, and Florencia Palacios, and Andrea Nicola Mazzarello, and Stefano Vergani, and Davide Bagnara, and Shih-Shih Chen, and Sophia Yancopoulos, and Aliki Xochelli, and Xiao-Jie Yan, and Jan A Burger, and Jacqueline C Barrientos, and Jonathan E Kolitz, and Steven L Allen, and Kostas Stamatopoulos, and Kanti R Rai, and Barbara Sherry, and Nicholas Chiorazzi
Cytokine transcriptional events during helper T cell subset differentiation.
August 1996, The Journal of experimental medicine,
Gerardo Ferrer, and Byeongho Jung, and Pui Yan Chiu, and Rukhsana Aslam, and Florencia Palacios, and Andrea Nicola Mazzarello, and Stefano Vergani, and Davide Bagnara, and Shih-Shih Chen, and Sophia Yancopoulos, and Aliki Xochelli, and Xiao-Jie Yan, and Jan A Burger, and Jacqueline C Barrientos, and Jonathan E Kolitz, and Steven L Allen, and Kostas Stamatopoulos, and Kanti R Rai, and Barbara Sherry, and Nicholas Chiorazzi
Chromatin remodeling and T helper subset differentiation.
June 2000, IUBMB life,
Gerardo Ferrer, and Byeongho Jung, and Pui Yan Chiu, and Rukhsana Aslam, and Florencia Palacios, and Andrea Nicola Mazzarello, and Stefano Vergani, and Davide Bagnara, and Shih-Shih Chen, and Sophia Yancopoulos, and Aliki Xochelli, and Xiao-Jie Yan, and Jan A Burger, and Jacqueline C Barrientos, and Jonathan E Kolitz, and Steven L Allen, and Kostas Stamatopoulos, and Kanti R Rai, and Barbara Sherry, and Nicholas Chiorazzi
Abnormal T-cell subpopulation function in CLL: excessive suppressor (T gamma) and deficient helper (T mu) activity with respect to B-cell proliferation.
March 1981, Blood,
Gerardo Ferrer, and Byeongho Jung, and Pui Yan Chiu, and Rukhsana Aslam, and Florencia Palacios, and Andrea Nicola Mazzarello, and Stefano Vergani, and Davide Bagnara, and Shih-Shih Chen, and Sophia Yancopoulos, and Aliki Xochelli, and Xiao-Jie Yan, and Jan A Burger, and Jacqueline C Barrientos, and Jonathan E Kolitz, and Steven L Allen, and Kostas Stamatopoulos, and Kanti R Rai, and Barbara Sherry, and Nicholas Chiorazzi
T-cell-Secreted TNFα Induces Emergency Myelopoiesis and Myeloid-Derived Suppressor Cell Differentiation in Cancer.
January 2019, Cancer research,
Gerardo Ferrer, and Byeongho Jung, and Pui Yan Chiu, and Rukhsana Aslam, and Florencia Palacios, and Andrea Nicola Mazzarello, and Stefano Vergani, and Davide Bagnara, and Shih-Shih Chen, and Sophia Yancopoulos, and Aliki Xochelli, and Xiao-Jie Yan, and Jan A Burger, and Jacqueline C Barrientos, and Jonathan E Kolitz, and Steven L Allen, and Kostas Stamatopoulos, and Kanti R Rai, and Barbara Sherry, and Nicholas Chiorazzi
Human T cell differentiation antigens characterizing a cytotoxic/suppressor T cell subset.
January 1981, Hybridoma,
Gerardo Ferrer, and Byeongho Jung, and Pui Yan Chiu, and Rukhsana Aslam, and Florencia Palacios, and Andrea Nicola Mazzarello, and Stefano Vergani, and Davide Bagnara, and Shih-Shih Chen, and Sophia Yancopoulos, and Aliki Xochelli, and Xiao-Jie Yan, and Jan A Burger, and Jacqueline C Barrientos, and Jonathan E Kolitz, and Steven L Allen, and Kostas Stamatopoulos, and Kanti R Rai, and Barbara Sherry, and Nicholas Chiorazzi
Strategies for T Helper Cell Subset Differentiation from Naïve Precursors.
January 2017, Methods in molecular biology (Clifton, N.J.),
Copied contents to your clipboard!