[Effect of transcortin on the corticosterone-transforming activity of cytosol from the rat liver]. 1988

A P Ulinskaĭte, and K I Krauialis, and A P Diashrius

The study of transcortin role in 3H-corticosterone metabolism has shown that transcortin of blood plasma from rats bearing Walker carcinosarcoma preserves the hormone conversion to dihydrocompounds 4 time less intensively than transcortin taken from healthy rats. Inactivated transcortin exerts no effect on the rate of formation of 5 beta-metabolites. Under the influence of homogeneous transcortin samples, a decrease in the content of 5 beta-reduced corticosterone metabolites is revealed to occur depending on transcortin concentration in the system. It is shown that in incubation systems where hormone is in the bound state the metabolism preserving capacity of transcortin depends on the temperature degree. The transcortin activity on corticosterone metabolism is supposed to be closely related to the intensity of its complexing with transcortin.

UI MeSH Term Description Entries
D007700 Kinetics The rate dynamics in chemical or physical systems.
D008099 Liver A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances. Livers
D002279 Carcinoma 256, Walker A transplantable carcinoma of the rat that originally appeared spontaneously in the mammary gland of a pregnant albino rat, and which now resembles a carcinoma in young transplants and a sarcoma in older transplants. (Stedman, 25th ed) Carcinosarcoma 256, Walker,Walker Carcinoma 256,Walker Carcinosarcoma 256
D003345 Corticosterone An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437)
D003600 Cytosol Intracellular fluid from the cytoplasm after removal of ORGANELLES and other insoluble cytoplasmic components. Cytosols
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D014156 Transcortin A serpin family member that binds to and transports GLUCOCORTICOIDS in the BLOOD. Corticosteroid-Binding Globulin,Serpin A6,Corticosteroid Binding Globulin
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

Related Publications

A P Ulinskaĭte, and K I Krauialis, and A P Diashrius
June 1976, Biochimica et biophysica acta,
A P Ulinskaĭte, and K I Krauialis, and A P Diashrius
January 1977, Biochemical Society transactions,
A P Ulinskaĭte, and K I Krauialis, and A P Diashrius
April 1975, Biochemical pharmacology,
A P Ulinskaĭte, and K I Krauialis, and A P Diashrius
July 1973, Brain research,
A P Ulinskaĭte, and K I Krauialis, and A P Diashrius
January 1991, Chemico-biological interactions,
A P Ulinskaĭte, and K I Krauialis, and A P Diashrius
April 1971, Canadian journal of biochemistry,
A P Ulinskaĭte, and K I Krauialis, and A P Diashrius
December 1971, Biochimica et biophysica acta,
A P Ulinskaĭte, and K I Krauialis, and A P Diashrius
September 1971, Journal of neurochemistry,
A P Ulinskaĭte, and K I Krauialis, and A P Diashrius
July 1973, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
Copied contents to your clipboard!