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Glucocorticoids delay parturition in rhesus monkeys, but the mechanism is unknown. This study was designed to determine the relationship between administration of glucocorticoids and prostaglandin levels in late pregnancy. Pregnant rhesus monkeys received intramuscular betamethasone (2 mg/day) from day 120 to day 133 of pregnancy. 13,14-Dihydro-15-keto-prostaglandin F2 alpha, progesterone, estradiol, estrone, and cortisol in amniotic fluid were measured by radioimmunoassay, and progesterone and estradiol were measured in the maternal serum. Among control animals, between 133 days and 160 days there were significant increases in adrenal size (p less than 0.05) and in amniotic fluid 13,14-Dihydro-15-keto-prostaglandin F2a metabolite, (p less than 0.005), estrone, and progesterone concentrations (p less than 0.05). The increase in adrenal size and the rise in amniotic fluid 13,14-Dihydro-15-keto-prostaglandin F2a metabolite, did not occur in betamethasone-treated monkeys. Maternal serum estradiol levels were suppressed immediately after treatment with betamethasone but recovered to control levels by day 160. Other changes in maternal serum and amniotic fluid sex steroid levels were sought but not observed. These data are consistent with the hypothesis that glucocorticoids delay primate parturition by altering intrauterine prostaglandin F2 alpha metabolism.
N H Dubin, and
J C Beck, and
J W Johnson, and
W T London, and
R B Ghodgaonkar, and
M J Perlstein
June 1975,
The Journal of endocrinology,
N H Dubin, and
J C Beck, and
J W Johnson, and
W T London, and
R B Ghodgaonkar, and
M J Perlstein
May 1978,
The American journal of clinical nutrition,
N H Dubin, and
J C Beck, and
J W Johnson, and
W T London, and
R B Ghodgaonkar, and
M J Perlstein
March 1982,
The Journal of clinical endocrinology and metabolism,
N H Dubin, and
J C Beck, and
J W Johnson, and
W T London, and
R B Ghodgaonkar, and
M J Perlstein
June 1977,
Biology of reproduction,
N H Dubin, and
J C Beck, and
J W Johnson, and
W T London, and
R B Ghodgaonkar, and
M J Perlstein
February 1966,
The Journal of infectious diseases,
N H Dubin, and
J C Beck, and
J W Johnson, and
W T London, and
R B Ghodgaonkar, and
M J Perlstein
October 1991,
The Journal of clinical endocrinology and metabolism,
N H Dubin, and
J C Beck, and
J W Johnson, and
W T London, and
R B Ghodgaonkar, and
M J Perlstein
June 1981,
Biology of reproduction,
N H Dubin, and
J C Beck, and
J W Johnson, and
W T London, and
R B Ghodgaonkar, and
M J Perlstein
January 2002,
Psychopharmacology,
N H Dubin, and
J C Beck, and
J W Johnson, and
W T London, and
R B Ghodgaonkar, and
M J Perlstein
October 1974,
Biochimica et biophysica acta,
N H Dubin, and
J C Beck, and
J W Johnson, and
W T London, and
R B Ghodgaonkar, and
M J Perlstein
June 1975,
American journal of obstetrics and gynecology,
