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A patient with stage IV advanced breast cancer with multiple metastasis (bones of the whole body, lungs) were treated by ovariectomy, administration of an non-steroidal antiestrogen (tamoxifen) and mild chemotherapeutic drugs, with favorable results. After four years, however, the patient had a relapse of the cancer. A steroidal antiestrogen (epitiostanol) was then administered with satisfactory results. When a breast cancer relapse occurs in patients once treated successfully with endocrinotherapy, a different form of endocrinotherapy should be tried. There is a possibility that the mechanism of action of Epitiostanol, which is regarded as a steroidal antiestrogen, is different from that of tamoxifen in which an estrogen receptor (ER) system is included.
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Gan to kagaku ryoho. Cancer & chemotherapy,
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Gan to kagaku ryoho. Cancer & chemotherapy,
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Y Konishi, and
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N Mituyama, and
T Tanaka, and
Y Oomine, and
Y Monden
December 2020,
Gan to kagaku ryoho. Cancer & chemotherapy,
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K Komaki, and
T Yamakawa, and
N Mituyama, and
T Tanaka, and
Y Oomine, and
Y Monden
August 1993,
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