-transparent.png){kind=logo}
Apolipoprotein(apo) C-II DNA, RNA and protein from a patient with a familial deficiency of apoC-II were evaluated and compared to normal individuals. No major defect of the apoC-II gene could be detected by Southern blot hybridization. Northern and slot blot analyses of total liver RNA documented normal levels of a normal sized apoC-II mRNA. Immunohistochemical studies of the liver of the apoC-II deficient patient revealed a normal to slightly elevated intracellular content of the C-II apolipoprotein. Plasma apoC-II was 3 to 5% of normal apoC-II levels and exhibited abnormal electrophoretic mobility on two dimensional gel electrophoresis and immunoblotting. We postulate that at the molecular level, the deficiency of apoC-II in the plasma of this patient results from a structural defect in the coding portion of the apoC-II gene leading to either defective secretion of cellular apoC-II or increased catabolism of a structurally defective apoC-II in plasma.
S S Fojo, and
G Baggio, and
C Gabelli, and
K Higuchi, and
M Bojanovski, and
R E Gregg, and
H B Brewer
March 1988,
Journal of lipid research,
S S Fojo, and
G Baggio, and
C Gabelli, and
K Higuchi, and
M Bojanovski, and
R E Gregg, and
H B Brewer
December 1988,
The Journal of biological chemistry,
S S Fojo, and
G Baggio, and
C Gabelli, and
K Higuchi, and
M Bojanovski, and
R E Gregg, and
H B Brewer
December 1989,
The Journal of biological chemistry,
S S Fojo, and
G Baggio, and
C Gabelli, and
K Higuchi, and
M Bojanovski, and
R E Gregg, and
H B Brewer
September 1985,
Journal of lipid research,
S S Fojo, and
G Baggio, and
C Gabelli, and
K Higuchi, and
M Bojanovski, and
R E Gregg, and
H B Brewer
August 1994,
Journal of lipid research,
S S Fojo, and
G Baggio, and
C Gabelli, and
K Higuchi, and
M Bojanovski, and
R E Gregg, and
H B Brewer
February 2016,
The Journal of pharmacology and experimental therapeutics,
S S Fojo, and
G Baggio, and
C Gabelli, and
K Higuchi, and
M Bojanovski, and
R E Gregg, and
H B Brewer
August 1981,
Metabolism: clinical and experimental,
S S Fojo, and
G Baggio, and
C Gabelli, and
K Higuchi, and
M Bojanovski, and
R E Gregg, and
H B Brewer
January 1986,
Advances in experimental medicine and biology,
S S Fojo, and
G Baggio, and
C Gabelli, and
K Higuchi, and
M Bojanovski, and
R E Gregg, and
H B Brewer
January 1998,
Ryoikibetsu shokogun shirizu,
S S Fojo, and
G Baggio, and
C Gabelli, and
K Higuchi, and
M Bojanovski, and
R E Gregg, and
H B Brewer
December 1994,
Nihon rinsho. Japanese journal of clinical medicine,
