-transparent.png){kind=logo}
The role of the alpha-tocopherol molecule isoprenoid chain in synaptosomal membrane protection from lipid peroxidation activation and phospholipase A2 damage was investigated. A comparative study of alpha-tocopherol analogs differing in the length of the isoprenoid chain revealed that the increase in the chain length results in a decrease of the efficiency of inhibition in the course of synaptosomal lipid peroxidation activation. This effect is due to the diminution of mobility of chromanols in the lipid bilayer which is associated with an increase in the length of the isoprenoid fragment. The decreased efficiency of lipid peroxidation inhibition resulting from the lengthening of the chromanol nucleus phytol chain is concomitant with the appearance of new stabilizing properties, e. g., the ability to protect synaptosomal membranes from the damaging action of phospholipase A2. This effect is lost with a decrease in the length of the chromanol isoprenoid chain.
A N Erin, and
N G Davitashvili, and
V E Kagan, and
E I Zakharova, and
I K Sarycheva
January 1987,
Doklady Akademii nauk SSSR,
A N Erin, and
N G Davitashvili, and
V E Kagan, and
E I Zakharova, and
I K Sarycheva
July 1991,
Biulleten' eksperimental'noi biologii i meditsiny,
A N Erin, and
N G Davitashvili, and
V E Kagan, and
E I Zakharova, and
I K Sarycheva
January 1985,
Problemy tuberkuleza,
A N Erin, and
N G Davitashvili, and
V E Kagan, and
E I Zakharova, and
I K Sarycheva
July 1986,
Biulleten' eksperimental'noi biologii i meditsiny,
A N Erin, and
N G Davitashvili, and
V E Kagan, and
E I Zakharova, and
I K Sarycheva
February 1998,
Chemistry and physics of lipids,
A N Erin, and
N G Davitashvili, and
V E Kagan, and
E I Zakharova, and
I K Sarycheva
February 1989,
Biochemical and biophysical research communications,
A N Erin, and
N G Davitashvili, and
V E Kagan, and
E I Zakharova, and
I K Sarycheva
August 1970,
The American journal of clinical nutrition,
A N Erin, and
N G Davitashvili, and
V E Kagan, and
E I Zakharova, and
I K Sarycheva
August 1984,
Biulleten' eksperimental'noi biologii i meditsiny,
A N Erin, and
N G Davitashvili, and
V E Kagan, and
E I Zakharova, and
I K Sarycheva
October 1988,
Biulleten' eksperimental'noi biologii i meditsiny,
A N Erin, and
N G Davitashvili, and
V E Kagan, and
E I Zakharova, and
I K Sarycheva
April 1999,
Free radical biology & medicine,
