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The biosynthesis of LH-RH was followed and evaluated in the hypothalamus of intact and castrated female rats after the infusion into the 3rd cerebral ventricle of L-3H-Glycine and its incorporation into the synthetized hormone. Incorporation of 3H-Gly into the LH--RH molecule that means biosynthesis of this hormone was found 30 min after the infusion of labeled amino acid. The incorporation rate in castrated animals was 2 times higher than in intact ones. Estradiol-17 beta only slightly depressed the LH--RH biosynthesis rate in castrated animals. Pretreatment with cycloheximide or puromycin decreased biosynthesis rate of the hormone by 50%. On the basis of cycloheximide and puromycin action it is suggested that the ribosomes are involved in the biosynthesis of LH--RH.
K Kochman, and
H Kochman, and
E Domański
January 1979,
Neuroendocrinology,
K Kochman, and
H Kochman, and
E Domański
November 1974,
Acta endocrinologica,
K Kochman, and
H Kochman, and
E Domański
May 1975,
Acta endocrinologica,
K Kochman, and
H Kochman, and
E Domański
November 1975,
Chemical & pharmaceutical bulletin,
K Kochman, and
H Kochman, and
E Domański
November 1973,
Berliner und Munchener tierarztliche Wochenschrift,
K Kochman, and
H Kochman, and
E Domański
August 1974,
Endocrinology,
K Kochman, and
H Kochman, and
E Domański
December 1983,
Nihon Sanka Fujinka Gakkai zasshi,
K Kochman, and
H Kochman, and
E Domański
January 1974,
Cell and tissue research,
K Kochman, and
H Kochman, and
E Domański
March 1983,
FEBS letters,
K Kochman, and
H Kochman, and
E Domański
September 1983,
Nihon Sanka Fujinka Gakkai zasshi,
