-transparent.png){kind=logo}
On the basis of karyotype analysis of the 6 groups of mouse--mouse hybridomas secreting monoclonal antibodies against 5 different antigens we found: (1) The karyotypic variability of clones in all six compared groups of hybridomas was consistent and was influenced neither by the specificity of secreted monoclonal antibodies nor by the character of antigen used for immunization (soluble or particulate). (2) The faster growing hybridomas had a lower mean chromosome number than the slower proliferating clones of the same origin. (3) Karyotypes of subclones isolated from ascites fluid of a mouse inoculated i.p. with clones permanently growing in vitro included a markedly higher mean chromosome number than the karyotypes of originally inoculated hybridoma cells.
P Kontsek, and
M Novák, and
E Kontseková
March 1985,
Molekuliarnaia genetika, mikrobiologiia i virusologiia,
P Kontsek, and
M Novák, and
E Kontseková
November 1988,
Acta virologica,
P Kontsek, and
M Novák, and
E Kontseková
March 1987,
European journal of immunology,
P Kontsek, and
M Novák, and
E Kontseková
May 1986,
Biochemical and biophysical research communications,
P Kontsek, and
M Novák, and
E Kontseková
January 1985,
Voprosy virusologii,
P Kontsek, and
M Novák, and
E Kontseková
January 1994,
Investigative urology (Berlin, Germany),
P Kontsek, and
M Novák, and
E Kontseková
May 1988,
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic],
P Kontsek, and
M Novák, and
E Kontseková
March 1985,
Sichuan yi xue yuan xue bao = Acta Academiae Medicinae Sichuan,
P Kontsek, and
M Novák, and
E Kontseková
December 2016,
Platelets,
P Kontsek, and
M Novák, and
E Kontseková
January 1996,
Pflugers Archiv : European journal of physiology,
