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A 36-yr-old woman was admitted for the investigation of diarrhea, fever, weight loss, and a recurrent painful, red eruption on her forearms. She was found to have total colonic involvement with a nonspecific ulcerative colitis. Vascular and extravascular amyloid (AA type) was present in biopsy specimens of the colon, duodenum, and stomach. There was clinical and radiographic evidence of splenic and hepatic amyloidosis. Moreover, the presence of extravascular colonic amyloid, the absence of renal involvement, the relatively early detection of amyloid, and the resolution of amyloid after treatment make this case unique.
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