BIOMAT Database Logo BIOMAT Database Logo

Vaginal Isolates of Candida glabrata Are Uniquely Susceptible to Ionophoric Killer Toxins Produced by Saccharomyces cerevisiae. 2021

Lance R Fredericks, and Mark D Lee, and Hannah R Eckert, and Shunji Li, and Mason A Shipley, and Cooper R Roslund, and Dina A Boikov, and Emily A Kizer, and Jack D Sobel, and Paul A Rowley
Department of Biological Sciences, University of Idaho, Moscow, Idaho, USA.

Compared to other species of Candida yeasts, the growth of Candida glabrata is inhibited by many different strains of Saccharomyces killer yeasts. The ionophoric K1 and K2 killer toxins are broadly inhibitory to all clinical isolates of C. glabrata from patients with recurrent vulvovaginal candidiasis, despite high levels of resistance to clinically relevant antifungal therapeutics.

UI MeSH Term Description Entries
D007476 Ionophores Chemical agents that increase the permeability of biological or artificial lipid membranes to specific ions. Most ionophores are relatively small organic molecules that act as mobile carriers within membranes or coalesce to form ion permeable channels across membranes. Many are antibiotics, and many act as uncoupling agents by short-circuiting the proton gradient across mitochondrial membranes. Ionophore
D008826 Microbial Sensitivity Tests Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses). Bacterial Sensitivity Tests,Drug Sensitivity Assay, Microbial,Minimum Inhibitory Concentration,Antibacterial Susceptibility Breakpoint Determination,Antibiogram,Antimicrobial Susceptibility Breakpoint Determination,Bacterial Sensitivity Test,Breakpoint Determination, Antibacterial Susceptibility,Breakpoint Determination, Antimicrobial Susceptibility,Fungal Drug Sensitivity Tests,Fungus Drug Sensitivity Tests,Sensitivity Test, Bacterial,Sensitivity Tests, Bacterial,Test, Bacterial Sensitivity,Tests, Bacterial Sensitivity,Viral Drug Sensitivity Tests,Virus Drug Sensitivity Tests,Antibiograms,Concentration, Minimum Inhibitory,Concentrations, Minimum Inhibitory,Inhibitory Concentration, Minimum,Inhibitory Concentrations, Minimum,Microbial Sensitivity Test,Minimum Inhibitory Concentrations,Sensitivity Test, Microbial,Sensitivity Tests, Microbial,Test, Microbial Sensitivity,Tests, Microbial Sensitivity
D002181 Candidiasis, Vulvovaginal Infection of the VULVA and VAGINA with a fungus of the genus CANDIDA. Moniliasis, Vulvovaginal,Vaginitis, Monilial,Candidiasis, Genital,Genital Vulvovaginal Candidiasis,Vaginal Yeast Infection,Vaginal Yeast Infections,Candidiasis, Genital Vulvovaginal,Genital Candidiasis,Infection, Vaginal Yeast,Infections, Vaginal Yeast,Monilial Vaginitis,Vulvovaginal Candidiasis,Vulvovaginal Candidiasis, Genital,Vulvovaginal Moniliasis,Yeast Infection, Vaginal,Yeast Infections, Vaginal
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000935 Antifungal Agents Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues. Anti-Fungal Agents,Antifungal Agent,Fungicides, Therapeutic,Antibiotics, Antifungal,Therapeutic Fungicides,Agent, Antifungal,Anti Fungal Agents,Antifungal Antibiotics
D012441 Saccharomyces cerevisiae A species of the genus SACCHAROMYCES, family Saccharomycetaceae, order Saccharomycetales, known as "baker's" or "brewer's" yeast. The dried form is used as a dietary supplement. Baker's Yeast,Brewer's Yeast,Candida robusta,S. cerevisiae,Saccharomyces capensis,Saccharomyces italicus,Saccharomyces oviformis,Saccharomyces uvarum var. melibiosus,Yeast, Baker's,Yeast, Brewer's,Baker Yeast,S cerevisiae,Baker's Yeasts,Yeast, Baker
D025141 Drug Resistance, Fungal The ability of fungi to resist or to become tolerant to chemotherapeutic agents, antifungal agents, or antibiotics. This resistance may be acquired through gene mutation. Antibiotic Resistance, Fungal,Antifungal Drug Resistance,Resistance, Antifungal Drug
D041221 Candida glabrata A species of MITOSPORIC FUNGI commonly found on the body surface. It causes opportunistic infections especially in immunocompromised patients. Torulopsis glabrata

Related Publications

Lance R Fredericks, and Mark D Lee, and Hannah R Eckert, and Shunji Li, and Mason A Shipley, and Cooper R Roslund, and Dina A Boikov, and Emily A Kizer, and Jack D Sobel, and Paul A Rowley
Killing of Torulopsis glabrata by Saccharomyces cerevisiae killer factor.
February 1976, Antimicrobial agents and chemotherapy,
Lance R Fredericks, and Mark D Lee, and Hannah R Eckert, and Shunji Li, and Mason A Shipley, and Cooper R Roslund, and Dina A Boikov, and Emily A Kizer, and Jack D Sobel, and Paul A Rowley
Occurrence of killer Candida glabrata clinical isolates.
July 2012, Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology],
Lance R Fredericks, and Mark D Lee, and Hannah R Eckert, and Shunji Li, and Mason A Shipley, and Cooper R Roslund, and Dina A Boikov, and Emily A Kizer, and Jack D Sobel, and Paul A Rowley
A new killer toxin produced by Saccharomyces cerevisiae.
May 1982, Current genetics,
Lance R Fredericks, and Mark D Lee, and Hannah R Eckert, and Shunji Li, and Mason A Shipley, and Cooper R Roslund, and Dina A Boikov, and Emily A Kizer, and Jack D Sobel, and Paul A Rowley
Uptake of 14C-chlorhexidine gluconate by Saccharomyces cerevisiae, Candida albicans and Candida glabrata.
July 1995, Letters in applied microbiology,
Lance R Fredericks, and Mark D Lee, and Hannah R Eckert, and Shunji Li, and Mason A Shipley, and Cooper R Roslund, and Dina A Boikov, and Emily A Kizer, and Jack D Sobel, and Paul A Rowley
Identification and susceptibility of clinical isolates of Candida spp. to killer toxins.
November 2018, Brazilian journal of biology = Revista brasleira de biologia,
Lance R Fredericks, and Mark D Lee, and Hannah R Eckert, and Shunji Li, and Mason A Shipley, and Cooper R Roslund, and Dina A Boikov, and Emily A Kizer, and Jack D Sobel, and Paul A Rowley
Epidemiological investigation of vaginal Saccharomyces cerevisiae isolates by a genotypic method.
February 1998, Journal of clinical microbiology,
Lance R Fredericks, and Mark D Lee, and Hannah R Eckert, and Shunji Li, and Mason A Shipley, and Cooper R Roslund, and Dina A Boikov, and Emily A Kizer, and Jack D Sobel, and Paul A Rowley
Toxins produced by Candida albicans.
January 1977, Contributions to microbiology and immunology,
Lance R Fredericks, and Mark D Lee, and Hannah R Eckert, and Shunji Li, and Mason A Shipley, and Cooper R Roslund, and Dina A Boikov, and Emily A Kizer, and Jack D Sobel, and Paul A Rowley
Activated lactoferrin and fluconazole synergism against Candida albicans and Candida glabrata vaginal isolates.
October 2004, The Journal of reproductive medicine,
Lance R Fredericks, and Mark D Lee, and Hannah R Eckert, and Shunji Li, and Mason A Shipley, and Cooper R Roslund, and Dina A Boikov, and Emily A Kizer, and Jack D Sobel, and Paul A Rowley
Molecular and epidemiological characterization of vaginal Saccharomyces cerevisiae isolates.
July 1999, Journal of clinical microbiology,
Lance R Fredericks, and Mark D Lee, and Hannah R Eckert, and Shunji Li, and Mason A Shipley, and Cooper R Roslund, and Dina A Boikov, and Emily A Kizer, and Jack D Sobel, and Paul A Rowley
Studies on the nature of the killer factor produced by Saccharomyces cerevisiae.
April 1968, Journal of general microbiology,
Copied contents to your clipboard!