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The effects of aflatoxin B1 on responses of the peripheral blood lymphocytes (PBL) of 2 normal animals to phytohemagglutinin, concanavalin-A, and pokeweed mitogen and of the PBL of 2 Mycobacterium bovis-infected animals to phytohemagglutinin and purified protein derivative of M bovis (PPD) were studied. Aflatoxin concentrations of greater than or equal to 10 microgram/ml significantly suppressed the lymphocyte response of normal animals to the phytomitogens. Lymphocyte response of M bovis-infected animals to specific antigen PPD was significantly suppressed at aflatoxin concentration of 0.5 microgram/ml. Fifty- to 100-fold higher concentrations of aflatoxin were required to produce 50% suppression of lymphocyte response to phytomitogens, as compared with that produced to PPD.
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D W Johnson, and
C J Mirocha, and
F F Soper, and
C O Thoen, and
C C Muscoplat, and
A F Weber
August 1974,
Clinical and experimental immunology,
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C O Thoen, and
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A F Weber
February 1978,
American journal of veterinary research,
P S Paul, and
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January 1981,
Allergie und Immunologie,
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A F Weber
June 1978,
American journal of veterinary research,
P S Paul, and
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April 1993,
Human antibodies and hybridomas,
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December 1967,
Lancet (London, England),
P S Paul, and
D W Johnson, and
C J Mirocha, and
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December 1974,
American journal of veterinary research,
P S Paul, and
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A F Weber
August 1970,
Nippon Ganka Gakkai zasshi,
P S Paul, and
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A F Weber
February 1995,
The Journal of veterinary medical science,
P S Paul, and
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C O Thoen, and
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A F Weber
November 1982,
Journal of cellular physiology,
