Declining risk of surgical intervention following early medical abortion: A time trend analysis. 2021

Amani Meaidi, and Bodil Hansdóttir Heimustovu, and Henriette Nguyen, and Tri Nguyen
Gynecology Clinic Hvidovre, Hvidovre, Denmark; Department of Gynaecology, Rigshospitalet, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address: amani-meaidi@live.dk.

To evaluate the time trend in risk of surgical intervention following early medical abortion. We conducted a retrospective observational study including all medical abortions induced before a gestational age of 63 days during the period 2008-2012 in a Danish gynecology clinic with a single provider deciding the necessity of subsequent surgical intervention. All included abortions were followed for 8 weeks from first medical administration. We extracted information on surgical intervention during follow-up and potential confounding variables from local and national health registers and assessed these according to calendar time. Multiple logistic regression provided an adjusted odds ratio of the association between calendar time and risk of surgical intervention. A total of 1372 abortions were induced on site during the study period. Surgical interventions on site decreased from 10.2% in 2008 to 2.6% in 2012 (p < 0.001). The decline was significant after adjustment of gestational age, maternal age, and reproductive history, odds ratio for 1-year increase 0.71 (95% CI: 0.59-0.86). Risk of surgical intervention following early medical abortion declined by time independent of known risk factors for surgical intervention in a setting with a single provider deciding the necessity of surgical intervention. Risk of surgical intervention following early medical abortion declined over time during a period without procedure changes and with no variations in known determinants of surgical intervention. This finding may indicate the effect of increasing provider experience in the reduction of risk of surgical intervention following early medical abortion.

UI MeSH Term Description Entries
D008423 Maternal Age The age of the mother in PREGNANCY. Age, Maternal,Ages, Maternal,Maternal Ages
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D005260 Female Females
D005865 Gestational Age The age of the conceptus, beginning from the time of FERTILIZATION. In clinical obstetrics, the gestational age is often estimated from the onset of the last MENSTRUATION which is about 2 weeks before OVULATION and fertilization. It is also estimated to begin from fertilization, estrus, coitus, or artificial insemination. Embryologic Age,Fetal Maturity, Chronologic,Chronologic Fetal Maturity,Fetal Age,Maturity, Chronologic Fetal,Age, Embryologic,Age, Fetal,Age, Gestational,Ages, Embryologic,Ages, Fetal,Ages, Gestational,Embryologic Ages,Fetal Ages,Gestational Ages
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000022 Abortion, Spontaneous Expulsion of the product of FERTILIZATION before completing the term of GESTATION and without deliberate interference. Abortion, Tubal,Early Pregnancy Loss,Miscarriage,Spontaneous Abortion,Abortions, Spontaneous,Abortions, Tubal,Early Pregnancy Losses,Loss, Early Pregnancy,Losses, Early Pregnancy,Miscarriages,Pregnancy Loss, Early,Pregnancy Losses, Early,Spontaneous Abortions,Tubal Abortion,Tubal Abortions
D000028 Abortion, Induced Intentional removal of a fetus from the uterus by any of a number of techniques. (POPLINE, 1978) Embryotomy,Abortion (Induced),Abortion Failure,Abortion History,Abortion Rate,Abortion Technics,Abortion Techniques,Abortion, Drug-Induced,Abortion, Rivanol,Abortion, Saline-Solution,Abortion, Soap-Solution,Anti-Abortion Groups,Fertility Control, Postconception,Induced Abortion,Previous Abortion,Abortion Failures,Abortion Histories,Abortion Rates,Abortion Technic,Abortion Technique,Abortion, Drug Induced,Abortion, Previous,Abortion, Saline Solution,Abortion, Soap Solution,Abortions (Induced),Abortions, Drug-Induced,Abortions, Induced,Abortions, Previous,Abortions, Rivanol,Abortions, Saline-Solution,Abortions, Soap-Solution,Anti Abortion Groups,Anti-Abortion Group,Drug-Induced Abortion,Drug-Induced Abortions,Embryotomies,Failure, Abortion,Failures, Abortion,Group, Anti-Abortion,Groups, Anti-Abortion,Histories, Abortion,History, Abortion,Induced Abortions,Postconception Fertility Control,Previous Abortions,Rate, Abortion,Rates, Abortion,Rivanol Abortion,Rivanol Abortions,Saline-Solution Abortion,Saline-Solution Abortions,Soap-Solution Abortion,Soap-Solution Abortions,Technic, Abortion,Technics, Abortion,Technique, Abortion,Techniques, Abortion
D000029 Abortion, Legal Termination of pregnancy under conditions allowed under local laws. (POPLINE Thesaurus, 1991) Abortion on Demand,Abortions, Legal,Legal Abortion,Legal Abortions
D016017 Odds Ratio The ratio of two odds. The exposure-odds ratio for case control data is the ratio of the odds in favor of exposure among cases to the odds in favor of exposure among noncases. The disease-odds ratio for a cohort or cross section is the ratio of the odds in favor of disease among the exposed to the odds in favor of disease among the unexposed. The prevalence-odds ratio refers to an odds ratio derived cross-sectionally from studies of prevalent cases. Cross-Product Ratio,Risk Ratio,Relative Odds,Cross Product Ratio,Cross-Product Ratios,Odds Ratios,Odds, Relative,Ratio, Cross-Product,Ratio, Risk,Ratios, Cross-Product,Ratios, Risk,Risk Ratios

Related Publications

Amani Meaidi, and Bodil Hansdóttir Heimustovu, and Henriette Nguyen, and Tri Nguyen
May 2019, American journal of obstetrics and gynecology,
Amani Meaidi, and Bodil Hansdóttir Heimustovu, and Henriette Nguyen, and Tri Nguyen
January 2003, Contraception,
Amani Meaidi, and Bodil Hansdóttir Heimustovu, and Henriette Nguyen, and Tri Nguyen
May 2011, BMJ (Clinical research ed.),
Amani Meaidi, and Bodil Hansdóttir Heimustovu, and Henriette Nguyen, and Tri Nguyen
August 1982, Lakartidningen,
Amani Meaidi, and Bodil Hansdóttir Heimustovu, and Henriette Nguyen, and Tri Nguyen
July 2009, Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology,
Amani Meaidi, and Bodil Hansdóttir Heimustovu, and Henriette Nguyen, and Tri Nguyen
October 2017, Health services research,
Amani Meaidi, and Bodil Hansdóttir Heimustovu, and Henriette Nguyen, and Tri Nguyen
July 2021, BMJ sexual & reproductive health,
Amani Meaidi, and Bodil Hansdóttir Heimustovu, and Henriette Nguyen, and Tri Nguyen
February 2016, American heart journal,
Amani Meaidi, and Bodil Hansdóttir Heimustovu, and Henriette Nguyen, and Tri Nguyen
March 2007, Human reproduction (Oxford, England),
Amani Meaidi, and Bodil Hansdóttir Heimustovu, and Henriette Nguyen, and Tri Nguyen
July 1979, Archives of gynecology,
Copied contents to your clipboard!