BIOMAT Database Logo BIOMAT Database Logo

Prognostic impact of lymph node micrometastasis in patients with gastric cancer. 2022

Atsushi Yamamoto, and Katsutoshi Shoda, and Yoshihiko Kawaguchi, and Hidenori Akaike, and Ryo Saito, and Naoki Ashizawa, and Koichi Takiguchi, and Shinji Furuya, and Naohiro Hosomura, and Hidetake Amemiya, and Hiromichi Kawaida, and Makoto Sudo, and Hiroshi Kono, and Kunio Mochizuki, and Daisuke Ichikawa
First Department of Surgery, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 4093898, Japan.

OBJECTIVE The clinical significance of lymph node micrometastasis (LNMM) remains controversial in gastric cancer (GC). In this study, we investigated the prognostic impact of LNMM in patients with GC. METHODS A total of 624 patients with pathologically lymph node metastasis-negative (pN0) and N1 status (pN1) who underwent gastrectomy between 2004 and 2018 were enrolled in this retrospective study. The diameter of tumor cell clusters in metastatic lymph nodes was measured in 120 patients with pN1 GC. RESULTS Patients with lymph node tumors < 1500 μm in diameter (LNMM) had a significantly better prognosis than those with tumors ≥ 1500 μm in diameter (p = 0.012; log-rank test). Cox's proportional hazards model revealed that LNMM (p = 0.016), several dissected lymph nodes (p = 0.049), and the provision of adjuvant chemotherapy (p = 0.002) were independent prognostic factors for the overall survival of patients with pN1 GC. There was no significant difference in the overall survival between patients with LNMM who received chemotherapy and those who did not (p = 0.332). CONCLUSIONS LNMM is associated with a favorable prognosis and maybe an independent prognostic marker in patients with pN1 GC. LNMM in GC may be considered a factor preventing adjuvant chemotherapy.

UI MeSH Term Description Entries
D008198 Lymph Nodes They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system. Lymph Node,Node, Lymph,Nodes, Lymph
D008207 Lymphatic Metastasis Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system. Lymph Node Metastasis,Lymph Node Metastases,Lymphatic Metastases,Metastasis, Lymph Node
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009367 Neoplasm Staging Methods which attempt to express in replicable terms the extent of the neoplasm in the patient. Cancer Staging,Staging, Neoplasm,Tumor Staging,TNM Classification,TNM Staging,TNM Staging System,Classification, TNM,Classifications, TNM,Staging System, TNM,Staging Systems, TNM,Staging, Cancer,Staging, TNM,Staging, Tumor,System, TNM Staging,Systems, TNM Staging,TNM Classifications,TNM Staging Systems
D011379 Prognosis A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations. Prognostic Factor,Prognostic Factors,Factor, Prognostic,Factors, Prognostic,Prognoses
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly

Related Publications

Atsushi Yamamoto, and Katsutoshi Shoda, and Yoshihiko Kawaguchi, and Hidenori Akaike, and Ryo Saito, and Naoki Ashizawa, and Koichi Takiguchi, and Shinji Furuya, and Naohiro Hosomura, and Hidetake Amemiya, and Hiromichi Kawaida, and Makoto Sudo, and Hiroshi Kono, and Kunio Mochizuki, and Daisuke Ichikawa
Prognostic effect of lymph node micrometastasis in patients with histologically node-negative gastric cancer.
October 2002, Annals of surgical oncology,
Atsushi Yamamoto, and Katsutoshi Shoda, and Yoshihiko Kawaguchi, and Hidenori Akaike, and Ryo Saito, and Naoki Ashizawa, and Koichi Takiguchi, and Shinji Furuya, and Naohiro Hosomura, and Hidetake Amemiya, and Hiromichi Kawaida, and Makoto Sudo, and Hiroshi Kono, and Kunio Mochizuki, and Daisuke Ichikawa
Prognostic impact of regional lymph node micrometastasis in patients with node-negative biliary cancer.
July 2010, Annals of surgery,
Atsushi Yamamoto, and Katsutoshi Shoda, and Yoshihiko Kawaguchi, and Hidenori Akaike, and Ryo Saito, and Naoki Ashizawa, and Koichi Takiguchi, and Shinji Furuya, and Naohiro Hosomura, and Hidetake Amemiya, and Hiromichi Kawaida, and Makoto Sudo, and Hiroshi Kono, and Kunio Mochizuki, and Daisuke Ichikawa
Prognostic impact of para-aortic lymph node micrometastasis in patients with regional node-positive biliary cancer.
May 2009, The British journal of surgery,
Atsushi Yamamoto, and Katsutoshi Shoda, and Yoshihiko Kawaguchi, and Hidenori Akaike, and Ryo Saito, and Naoki Ashizawa, and Koichi Takiguchi, and Shinji Furuya, and Naohiro Hosomura, and Hidetake Amemiya, and Hiromichi Kawaida, and Makoto Sudo, and Hiroshi Kono, and Kunio Mochizuki, and Daisuke Ichikawa
Clinical impact of micrometastasis of the lymph node in gastric cancer.
July 2003, The American surgeon,
Atsushi Yamamoto, and Katsutoshi Shoda, and Yoshihiko Kawaguchi, and Hidenori Akaike, and Ryo Saito, and Naoki Ashizawa, and Koichi Takiguchi, and Shinji Furuya, and Naohiro Hosomura, and Hidetake Amemiya, and Hiromichi Kawaida, and Makoto Sudo, and Hiroshi Kono, and Kunio Mochizuki, and Daisuke Ichikawa
Prognostic relevance of immunohistochemically detected lymph node micrometastasis in patients with gastric carcinoma.
June 2002, Cancer,
Atsushi Yamamoto, and Katsutoshi Shoda, and Yoshihiko Kawaguchi, and Hidenori Akaike, and Ryo Saito, and Naoki Ashizawa, and Koichi Takiguchi, and Shinji Furuya, and Naohiro Hosomura, and Hidetake Amemiya, and Hiromichi Kawaida, and Makoto Sudo, and Hiroshi Kono, and Kunio Mochizuki, and Daisuke Ichikawa
Should lymph node micrometastasis be considered in node staging for gastric cancer?: the significance of lymph node micrometastasis in gastric cancer.
March 2015, Annals of surgical oncology,
Atsushi Yamamoto, and Katsutoshi Shoda, and Yoshihiko Kawaguchi, and Hidenori Akaike, and Ryo Saito, and Naoki Ashizawa, and Koichi Takiguchi, and Shinji Furuya, and Naohiro Hosomura, and Hidetake Amemiya, and Hiromichi Kawaida, and Makoto Sudo, and Hiroshi Kono, and Kunio Mochizuki, and Daisuke Ichikawa
Impact of lymph node micrometastasis in patients with pancreatic head cancer.
March 2007, World journal of surgery,
Atsushi Yamamoto, and Katsutoshi Shoda, and Yoshihiko Kawaguchi, and Hidenori Akaike, and Ryo Saito, and Naoki Ashizawa, and Koichi Takiguchi, and Shinji Furuya, and Naohiro Hosomura, and Hidetake Amemiya, and Hiromichi Kawaida, and Makoto Sudo, and Hiroshi Kono, and Kunio Mochizuki, and Daisuke Ichikawa
Lymph node micrometastasis in node negative early gastric cancer.
April 2009, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology,
Atsushi Yamamoto, and Katsutoshi Shoda, and Yoshihiko Kawaguchi, and Hidenori Akaike, and Ryo Saito, and Naoki Ashizawa, and Koichi Takiguchi, and Shinji Furuya, and Naohiro Hosomura, and Hidetake Amemiya, and Hiromichi Kawaida, and Makoto Sudo, and Hiroshi Kono, and Kunio Mochizuki, and Daisuke Ichikawa
Clinical Significance of Lymph Node Micrometastasis in pN0 Gastric Cancer Patients.
January 2021, Gastroenterology research and practice,
Atsushi Yamamoto, and Katsutoshi Shoda, and Yoshihiko Kawaguchi, and Hidenori Akaike, and Ryo Saito, and Naoki Ashizawa, and Koichi Takiguchi, and Shinji Furuya, and Naohiro Hosomura, and Hidetake Amemiya, and Hiromichi Kawaida, and Makoto Sudo, and Hiroshi Kono, and Kunio Mochizuki, and Daisuke Ichikawa
[Prognostic significance of lymph node micrometastasis in colorectal cancer].
July 2003, Ai zheng = Aizheng = Chinese journal of cancer,
Copied contents to your clipboard!