Does a high-fat diet-induced obesity model brown adipose tissue thermogenesis? A systematic review. 2021

Gabriela S Perez, and Gabriele D S Cordeiro, and Lucimeire S Santos, and Djane D A Espírito-Santo, and Gilson T Boaventura, and Jairza M Barreto-Medeiros
Graduate Program of Food Nutrition and Health, Department of Nutrition Science, Federal University of Bahia, Brazil.

BACKGROUND In this systematic review, we analysed studies that assessed the brown adipose tissue (BAT) activity in the high-fat/cafeteria diet model of obesity in rats. METHODS Scopus, PubMed, Embase, and ScienceDirect databases were searched from January 2017 to November 2017. Using specific combinations of medical subject heading (MeSH) descriptors, seven papers remained after the inclusion and exclusion criteria. RESULTS Most papers showed an increase in BAT thermogenesis in rodents fed high-fat/cafeteria diet. Some studies did not mention the diet composition or housing temperature, and the most of them investigated the thermogenesis superficially, being limited to the analysis of the UCP 1 expression. CONCLUSIONS Despite the consolidated use of high-fat/cafeteria diets as a model to induce obesity, the identification of the energy expenditure arm has been slow, especially the direct quantitative assessment of the contribution of BAT to the increase in metabolic rate in rats fed a cafeteria/high-fat diet.

UI MeSH Term Description Entries

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