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The proliferation of lens epithelial cells remaining attached to the capsule after extracapsular cataract extraction represents a potential cause of posterior capsule opacification. In view of the reported mitogenic effects of eye derived growth factors on lens epithelial cells in animal studies, we determined to establish whether the human retina produces a factor capable of inducing a similar response in human lens epithelial (HLE) cells. We report that an extract of the human neural retina is capable of increasing the proliferative capacity of HLE cells in culture by 50%. The possible mechanisms are discussed. The presence of such a growth factor in the human eye would have important consequences for the epithelial cells remaining after cataract surgery.
T J Jacob, and
R C Humphry, and
E G Davies, and
G M Thompson
July 1997,
Current eye research,
T J Jacob, and
R C Humphry, and
E G Davies, and
G M Thompson
November 1985,
Experimental eye research,
T J Jacob, and
R C Humphry, and
E G Davies, and
G M Thompson
January 1990,
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie,
T J Jacob, and
R C Humphry, and
E G Davies, and
G M Thompson
January 1982,
Transactions of the ophthalmological societies of the United Kingdom,
T J Jacob, and
R C Humphry, and
E G Davies, and
G M Thompson
March 2009,
Cellular and molecular bioengineering,
T J Jacob, and
R C Humphry, and
E G Davies, and
G M Thompson
October 1997,
Molecular vision,
T J Jacob, and
R C Humphry, and
E G Davies, and
G M Thompson
January 2012,
Molecular vision,
T J Jacob, and
R C Humphry, and
E G Davies, and
G M Thompson
August 2003,
Investigative ophthalmology & visual science,
T J Jacob, and
R C Humphry, and
E G Davies, and
G M Thompson
January 2013,
Molecular vision,
T J Jacob, and
R C Humphry, and
E G Davies, and
G M Thompson
October 2003,
Molecular vision,
