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Contrast media occasionally produce ventricular fibrillation during coronary angiography. We compared the fibrillatory propensity of the conventional ionic contrast medium, Hypaque-76 (H76) to the low osmolar ionic dimer Hexabrix (HB) and to the nonionic agent Omnipaque (OM) in 20 open chest anesthetized dogs. Intracoronary injection of 6 mL of contrast medium produced spontaneous ventricular fibrillation in four of ten dogs with H76, compared with two of ten with HB, and zero of ten with OM (P = .07). The induction of two premature beats by programmed stimulation of the myocardium during injection of 4 mL of contrast medium produced ventricular fibrillation in ten of ten dogs with H76, compared with three of ten with HB, and zero of ten with OM (P less than .001). Both H76 and HB produced ventricular fibrillation in ten of ten dogs when three premature beats were induced, compared with two of ten dogs with OM (P less than .001). Four mL H76 produced a 109 +/- 18 msec increase in the QT interval, compared with an 82 +/- 17 msec increase with HB, and a 45 +/- 12 msec increase with OM. We conclude that both low osmolar HB and OM are less fibrillatory than the conventional ionic medium H76, and that the nonionic medium OM is less fibrillatory than the ionic dimer contrast medium HB.
Z E Piao, and
D K Murdock, and
M H Hwang, and
R M Raymond, and
P J Scanlon
September 1988,
Investigative radiology,
Z E Piao, and
D K Murdock, and
M H Hwang, and
R M Raymond, and
P J Scanlon
July 1984,
Radiology,
Z E Piao, and
D K Murdock, and
M H Hwang, and
R M Raymond, and
P J Scanlon
December 1989,
AJR. American journal of roentgenology,
Z E Piao, and
D K Murdock, and
M H Hwang, and
R M Raymond, and
P J Scanlon
August 1990,
Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry,
Z E Piao, and
D K Murdock, and
M H Hwang, and
R M Raymond, and
P J Scanlon
April 1989,
Investigative radiology,
Z E Piao, and
D K Murdock, and
M H Hwang, and
R M Raymond, and
P J Scanlon
January 1989,
Cardiovascular and interventional radiology,
Z E Piao, and
D K Murdock, and
M H Hwang, and
R M Raymond, and
P J Scanlon
January 1995,
Acta radiologica. Supplementum,
Z E Piao, and
D K Murdock, and
M H Hwang, and
R M Raymond, and
P J Scanlon
April 1989,
La Radiologia medica,
Z E Piao, and
D K Murdock, and
M H Hwang, and
R M Raymond, and
P J Scanlon
January 1988,
Acta radiologica (Stockholm, Sweden : 1987),
Z E Piao, and
D K Murdock, and
M H Hwang, and
R M Raymond, and
P J Scanlon
January 1984,
Investigative radiology,
