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Eighty-five patients with endospcopically confirmed duodenal or pyloric canal ulcers entered a double blind trial with 1200 mg of cimetidine per day or placebo for 6 weeks. Eighty-four per cent of patients treated with cimetidine and 38 percent of those receiving placebo healed their ulcers (P less than 0.001). Measurement of basal acid output and maximal acid output before and after treatment showed no significant change but patients who failed to heal their ulcers had a higher basal acid output and maximal acid output than those who healed. Patients who smoked or drank alcohol had the same healing rate as abstainers. Sity-seven patients with duodenal ulceration healed by a 6-week course of cimetidine were randomly allocated to 400 mg of cimetidine twice daily or placebo in the maintenance trial. Actuarial analysis of the number of relapses in each group demonstrates that cimetidine is highly effective in preventing relapse.
D J Hetzel, and
P J Hansky, and
D J Shearman, and
M G Korman, and
R Hecker, and
G J Taggart, and
R Jackson, and
B W Gabb
March 1979,
The Medical journal of Malaysia,
D J Hetzel, and
P J Hansky, and
D J Shearman, and
M G Korman, and
R Hecker, and
G J Taggart, and
R Jackson, and
B W Gabb
January 1980,
The British journal of clinical practice,
D J Hetzel, and
P J Hansky, and
D J Shearman, and
M G Korman, and
R Hecker, and
G J Taggart, and
R Jackson, and
B W Gabb
May 1982,
Journal of the Royal Society of Medicine,
D J Hetzel, and
P J Hansky, and
D J Shearman, and
M G Korman, and
R Hecker, and
G J Taggart, and
R Jackson, and
B W Gabb
June 1979,
Gut,
D J Hetzel, and
P J Hansky, and
D J Shearman, and
M G Korman, and
R Hecker, and
G J Taggart, and
R Jackson, and
B W Gabb
June 1977,
Lancet (London, England),
D J Hetzel, and
P J Hansky, and
D J Shearman, and
M G Korman, and
R Hecker, and
G J Taggart, and
R Jackson, and
B W Gabb
April 1977,
Lancet (London, England),
D J Hetzel, and
P J Hansky, and
D J Shearman, and
M G Korman, and
R Hecker, and
G J Taggart, and
R Jackson, and
B W Gabb
April 1982,
Drug and therapeutics bulletin,
D J Hetzel, and
P J Hansky, and
D J Shearman, and
M G Korman, and
R Hecker, and
G J Taggart, and
R Jackson, and
B W Gabb
October 1983,
Scandinavian journal of gastroenterology,
D J Hetzel, and
P J Hansky, and
D J Shearman, and
M G Korman, and
R Hecker, and
G J Taggart, and
R Jackson, and
B W Gabb
January 1985,
Current medical research and opinion,
D J Hetzel, and
P J Hansky, and
D J Shearman, and
M G Korman, and
R Hecker, and
G J Taggart, and
R Jackson, and
B W Gabb
July 1986,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
