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The effect of epinephrine on neutrophil (PMN) kinetics in rabbit lungs was evaluated by measuring the retention of radiolabeled PMN's in the lung, the exchange rate between the marginated and circulating pools of PMN's, and the erythrocyte (RBC) transit time. Epinephrine treatment decreased RBC transit times and increased exchange rates in the regions with the shortest transit times but did not change the pulmonary recovery of radiolabeled PMN's. When regions of similar RBC transit time were compared, epinephrine did not affect PMN retention at short transit times but did produce greater retention at long transit times. These data suggest that the major effect of epinephrine was to increase the proportion of the lung having short RBC transit times and fast exchange rates between the marginated and circulating pools. However, this effect did not decrease the overall retention of PMN's most likely because it was balanced by recruitment of additional capillary segments, which increased PMN retention in regions with longer transit times.
C M Doerschuk, and
M F Allard, and
S Lee, and
M L Brumwell, and
J C Hogg
October 1989,
The New England journal of medicine,
C M Doerschuk, and
M F Allard, and
S Lee, and
M L Brumwell, and
J C Hogg
August 1990,
Clinical science (London, England : 1979),
C M Doerschuk, and
M F Allard, and
S Lee, and
M L Brumwell, and
J C Hogg
April 1982,
The Journal of clinical investigation,
C M Doerschuk, and
M F Allard, and
S Lee, and
M L Brumwell, and
J C Hogg
October 1991,
The American journal of physiology,
C M Doerschuk, and
M F Allard, and
S Lee, and
M L Brumwell, and
J C Hogg
May 1989,
Journal of applied physiology (Bethesda, Md. : 1985),
C M Doerschuk, and
M F Allard, and
S Lee, and
M L Brumwell, and
J C Hogg
January 1972,
Anesthesia and analgesia,
C M Doerschuk, and
M F Allard, and
S Lee, and
M L Brumwell, and
J C Hogg
January 1991,
Annals of the New York Academy of Sciences,
C M Doerschuk, and
M F Allard, and
S Lee, and
M L Brumwell, and
J C Hogg
April 1992,
Nuclear medicine communications,
C M Doerschuk, and
M F Allard, and
S Lee, and
M L Brumwell, and
J C Hogg
July 2010,
Chemical research in toxicology,
C M Doerschuk, and
M F Allard, and
S Lee, and
M L Brumwell, and
J C Hogg
August 1977,
Journal of applied physiology: respiratory, environmental and exercise physiology,
