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We used a recombinant cDNA probe for human chromogranin A to measure the expression of mRNA encoded by this gene in a variety of normal human tissues and tumor specimens using Northern blot and in situ hybridization analysis. With few exceptions, the expression of chromogranin A mRNA appears to be restricted to normal tissues and tumors of neuroendocrine lineage. However, we have detected mRNA expression of this gene in 1 of 14 cell lines and 2 of 13 tumor specimens of colon adenocarcinoma. The finding of chromogranin A expression in some colon carcinomas suggests that a previously unrecognized subgroup of these tumors has neuroendocrine features. The detection of this subgroup demonstrates the potential for improving tumor classification through the use of techniques and reagents developed by recombinant DNA technology.
L J Helman, and
A F Gazdar, and
J G Park, and
P S Cohen, and
J D Cotelingam, and
M A Israel
March 2010,
Nan fang yi ke da xue xue bao = Journal of Southern Medical University,
L J Helman, and
A F Gazdar, and
J G Park, and
P S Cohen, and
J D Cotelingam, and
M A Israel
July 2005,
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society,
L J Helman, and
A F Gazdar, and
J G Park, and
P S Cohen, and
J D Cotelingam, and
M A Israel
January 1993,
EXS,
L J Helman, and
A F Gazdar, and
J G Park, and
P S Cohen, and
J D Cotelingam, and
M A Israel
January 1997,
Clinical cancer research : an official journal of the American Association for Cancer Research,
L J Helman, and
A F Gazdar, and
J G Park, and
P S Cohen, and
J D Cotelingam, and
M A Israel
June 2006,
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc,
L J Helman, and
A F Gazdar, and
J G Park, and
P S Cohen, and
J D Cotelingam, and
M A Israel
November 1983,
The Journal of clinical endocrinology and metabolism,
L J Helman, and
A F Gazdar, and
J G Park, and
P S Cohen, and
J D Cotelingam, and
M A Israel
April 2006,
World journal of surgery,
L J Helman, and
A F Gazdar, and
J G Park, and
P S Cohen, and
J D Cotelingam, and
M A Israel
May 2003,
The Prostate,
L J Helman, and
A F Gazdar, and
J G Park, and
P S Cohen, and
J D Cotelingam, and
M A Israel
September 2006,
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society,
L J Helman, and
A F Gazdar, and
J G Park, and
P S Cohen, and
J D Cotelingam, and
M A Israel
April 1995,
International journal of oncology,
