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The therapeutic efficacy of gentamicin given once or three times a day was compared in a model of experimental renal infection in rats. The same amount of gentamicin given either in a single injection or three injections a day produced no statistically significant difference in the treatment of incipient infection. The effect of this mode of administration on advanced infection depended on the length of the therapy. After five days, administration of the same dose given in a single injection or three injections did not result in significant differences. After ten days the therapy proved more effective when gentamicin was injected three times a day. In comparison a single daily dose, amounting to two thirds of the total dose when given three times a day every eight hours, revealed after five days of therapy a statistically significantly lower bacterial count in the kidney than three daily injections of gentamicin.
M Hatala, and
J Morávek, and
V Prát, and
O Schück, and
M Liŝka, and
J Spousta
October 1974,
Antimicrobial agents and chemotherapy,
M Hatala, and
J Morávek, and
V Prát, and
O Schück, and
M Liŝka, and
J Spousta
May 1997,
Ugeskrift for laeger,
M Hatala, and
J Morávek, and
V Prát, and
O Schück, and
M Liŝka, and
J Spousta
October 2008,
Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale,
M Hatala, and
J Morávek, and
V Prát, and
O Schück, and
M Liŝka, and
J Spousta
July 1999,
Bone marrow transplantation,
M Hatala, and
J Morávek, and
V Prát, and
O Schück, and
M Liŝka, and
J Spousta
January 1999,
Journal of pediatric hematology/oncology,
M Hatala, and
J Morávek, and
V Prát, and
O Schück, and
M Liŝka, and
J Spousta
June 1979,
JAMA,
M Hatala, and
J Morávek, and
V Prát, and
O Schück, and
M Liŝka, and
J Spousta
January 1997,
Antimicrobial agents and chemotherapy,
M Hatala, and
J Morávek, and
V Prát, and
O Schück, and
M Liŝka, and
J Spousta
April 2004,
Journal of the Medical Association of Thailand = Chotmaihet thangphaet,
M Hatala, and
J Morávek, and
V Prát, and
O Schück, and
M Liŝka, and
J Spousta
March 2003,
Anales de pediatria (Barcelona, Spain : 2003),
M Hatala, and
J Morávek, and
V Prát, and
O Schück, and
M Liŝka, and
J Spousta
June 1991,
The Journal of hospital infection,
