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BACKGROUND Progressive ischemic stroke is a common cerebrovascular disease with high morbidity. This study aimed to investigate the relationship between changes of Thromboxane B2 (TXB2), 6-keto-prostaglandin Fla (6-k-PGFla), and blood glucose (BG) levels with progressive ischemic stroke. METHODS A total of 106 patients with progressive ischemic stroke admitted to our hospital from December 2016 to December 2018 were recruited as the observation group, and 110 patients who received physical examination in our hospital during the same period were selected as the control group. The levels of TXB2, 6-k-PGFla, and BG in different groups were compared, the related risk factors affecting the prognosis of patients with progressive ischemic stroke were analyzed, and the receiver operating characteristic (ROC) curve was drawn to evaluate the predictive value of TXB2, 6-k-PGFla, and BG for the prognostic mortality of patients with progressive ischemic stroke. RESULTS The levels of TXB2, 6-k-PGFla, and BG in the observation group were significantly higher than those in the control group (P<0.05). The prognostic mortality of participants with abnormally increased expression of TXB2, 6-k-PGFla, and BG was significantly higher than that of patients with normal expression of TXB2, 6-k-PGFla, and BG (P<0.05). Hypertension, diabetes, collateral circulatory disorders, hyperlipidemia, TXB2 (abnormal increase), 6-k-PGFla (abnormal increase), and BG (abnormal increase) were risk factors affecting the prognosis of patients with progressive ischemic stroke (P<0.05). The area under the curve (AUC) of the ROC curve showed that TXB2, 6-k-PGFla, BG, and the combination of them were 0.846, 0.893, 0.835, and 0.971, respectively, showing that the AUC of the combination of them was the largest. CONCLUSIONS Hypertension, diabetes, collateral circulatory disorders, hyperlipidemia, TXB2 (abnormal increase), 6-k-PGFla (abnormal increase), and BG (abnormal increase) are risk factors affecting the prognosis of patients with progressive ischemic stroke. The combined detection of the 3 indicators showed high sensitivity and specificity in evaluating the prognostic mortality of patients with progressive ischemic stroke, indicating that clinicians might improve the early diagnosis rate of progressive ischemic stroke by combining the detection of TXB2, 6-k-PGFla, and BG to predict the prognosis of patients.
Lunbo Liu, and
Aiping Feng, and
Chen Du, and
Changmin Qi
March 1994,
Research communications in chemical pathology and pharmacology,
Lunbo Liu, and
Aiping Feng, and
Chen Du, and
Changmin Qi
August 1990,
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases,
Lunbo Liu, and
Aiping Feng, and
Chen Du, and
Changmin Qi
September 1984,
Prostaglandins, leukotrienes, and medicine,
Lunbo Liu, and
Aiping Feng, and
Chen Du, and
Changmin Qi
July 1987,
Klinika oczna,
Lunbo Liu, and
Aiping Feng, and
Chen Du, and
Changmin Qi
June 1987,
Zhonghua nei ke za zhi,
Lunbo Liu, and
Aiping Feng, and
Chen Du, and
Changmin Qi
January 1985,
Prostaglandins, leukotrienes, and medicine,
Lunbo Liu, and
Aiping Feng, and
Chen Du, and
Changmin Qi
June 1981,
American journal of obstetrics and gynecology,
Lunbo Liu, and
Aiping Feng, and
Chen Du, and
Changmin Qi
March 1990,
Nihon Geka Gakkai zasshi,
Lunbo Liu, and
Aiping Feng, and
Chen Du, and
Changmin Qi
January 1987,
Zhong xi yi jie he za zhi = Chinese journal of modern developments in traditional medicine,
Lunbo Liu, and
Aiping Feng, and
Chen Du, and
Changmin Qi
January 1988,
Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao,
