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Bone defect is usually difficult to recover quickly, and bone scaffold transplantation is considered to be an effective method. Biomaterials have a wide range of application prospects in bone tissue repair, and the two key problems are the selection of materials and cells. The object of this study was to discuss the structural characteristics of bone scaffold materials and their effects on bone repair in vivo. The chitin-hydroxyapatite (HAP)-collagen composite scaffolds (CHCS) was prepared with epichlorohydrin (ECH) as crosslinking agent. The structure was characterized and the compressive strength, porosity, water absorbency and stability were investigated. The biocompatibility and osteogenic differentiation of CHCS in vitro were detected, and the effect of defect repair in vivo was evaluated. The results suggested that HAP not only enhanced the compressive strength of CHCS, but also promoted the formation of calcium nodules due to its bone conductivity. Histological staining showed that collagen promoted collagen deposition and new bone formation. X-ray images also indicated that CHCS transplantation accelerated bone repair. Therefore, CHCs has immense potential in bone regeneration.
Fei Xing, and
Zhe Chi, and
Rongxue Yang, and
Derong Xu, and
Jiufa Cui, and
Yufen Huang, and
Chuanli Zhou, and
Chenguang Liu
April 2020,
ACS applied materials & interfaces,
Fei Xing, and
Zhe Chi, and
Rongxue Yang, and
Derong Xu, and
Jiufa Cui, and
Yufen Huang, and
Chuanli Zhou, and
Chenguang Liu
March 2021,
Biomedical materials (Bristol, England),
Fei Xing, and
Zhe Chi, and
Rongxue Yang, and
Derong Xu, and
Jiufa Cui, and
Yufen Huang, and
Chuanli Zhou, and
Chenguang Liu
April 2023,
Biomedical materials (Bristol, England),
Fei Xing, and
Zhe Chi, and
Rongxue Yang, and
Derong Xu, and
Jiufa Cui, and
Yufen Huang, and
Chuanli Zhou, and
Chenguang Liu
January 2022,
Journal of functional biomaterials,
Fei Xing, and
Zhe Chi, and
Rongxue Yang, and
Derong Xu, and
Jiufa Cui, and
Yufen Huang, and
Chuanli Zhou, and
Chenguang Liu
January 2023,
Scientific reports,
Fei Xing, and
Zhe Chi, and
Rongxue Yang, and
Derong Xu, and
Jiufa Cui, and
Yufen Huang, and
Chuanli Zhou, and
Chenguang Liu
February 2015,
The Journal of oral implantology,
Fei Xing, and
Zhe Chi, and
Rongxue Yang, and
Derong Xu, and
Jiufa Cui, and
Yufen Huang, and
Chuanli Zhou, and
Chenguang Liu
March 2018,
Bioactive materials,
Fei Xing, and
Zhe Chi, and
Rongxue Yang, and
Derong Xu, and
Jiufa Cui, and
Yufen Huang, and
Chuanli Zhou, and
Chenguang Liu
June 2016,
Materials science & engineering. C, Materials for biological applications,
Fei Xing, and
Zhe Chi, and
Rongxue Yang, and
Derong Xu, and
Jiufa Cui, and
Yufen Huang, and
Chuanli Zhou, and
Chenguang Liu
February 2011,
Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology,
Fei Xing, and
Zhe Chi, and
Rongxue Yang, and
Derong Xu, and
Jiufa Cui, and
Yufen Huang, and
Chuanli Zhou, and
Chenguang Liu
February 2012,
Journal of functional biomaterials,
