Bullous skin diseases are characterised by a large group of diseases, where the essential clinical feature is fluid-filled skin lesions. Physicians in many different specialities can meet patients with bullous skin diseases, which include a wide range of skin diseases from mild cases to very severe and life-threating diseases. The aim of this review is to provide systematically approach of how make the accurate diagnosis, using important and basic elements of history taking, clinical and paraclinical examination.