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Changes in serotonergic (5HT) neurotransmission may mediate the therapeutic actions of some antidepressant drugs. In the present study, the 5HT precursor L-tryptophan (L-TRP) was administered intravenously to nine depressed patients before and during treatment with the triazolopyridine antidepressant trazodone (TRZ). Neuroendocrine, subjective mood, and cardiovascular responses to L-TRP were assessed. Unlike tricyclic antidepressants and monoamine oxidase inhibitors, TRZ did not enhance the prolactin response to L-TRP and had little effect on other measures. Since other studies indicate that the TRP-induced increase of prolactin in humans may reflect 5HT function, the present study suggests that TRZ treatment does not enhance net 5HT function in depressed patients.
L H Price, and
D S Charney, and
G R Heninger
December 1988,
Journal of clinical psychopharmacology,
L H Price, and
D S Charney, and
G R Heninger
June 1995,
International clinical psychopharmacology,
L H Price, and
D S Charney, and
G R Heninger
January 1974,
International journal of clinical pharmacology, therapy and toxicology,
L H Price, and
D S Charney, and
G R Heninger
July 1979,
Psychopharmacology bulletin,
L H Price, and
D S Charney, and
G R Heninger
January 1982,
Neuropsychobiology,
L H Price, and
D S Charney, and
G R Heninger
January 1984,
Psychopathology,
L H Price, and
D S Charney, and
G R Heninger
January 1989,
Progress in neuro-psychopharmacology & biological psychiatry,
L H Price, and
D S Charney, and
G R Heninger
January 1989,
Journal of geriatric psychiatry and neurology,
L H Price, and
D S Charney, and
G R Heninger
June 1982,
The American journal of psychiatry,
L H Price, and
D S Charney, and
G R Heninger
January 1998,
Hospital medicine (London, England : 1998),
