The Center for Epidemiologic Studies Depression (CES-D) Scale has been widely used to measure depressive symptoms. This study compared the measurement invariances for one-, two-, three-, and four-factor models of the CES-D across English-speaking Whites and Asians: White Americans, White Australians, Indians, Filipinos, and Singaporeans. White Americans and Australians, Indians, Filipinos, and Singaporeans English speakers (782 men and 824 women) whose ages ranged from 20 to 79 years, completed the CES-D. They were recruited from the data pool of the 2013 and 2014 Coping and Health Survey. Confirmatory factor analyses indicated that the original four-factor model showed the best fit, compared to the other models. Mean and covariance structure analyses showed that the factor means of the CES-D subscales among Whites were significantly lower than were those among Asians; the score gap was particularly high between Whites and Indians. Additionally, Indians scored the highest on all subscales of the CES-D compared to all other countries. Overall, CES-D scores among Whites were lower than those among Asians.