Air pollutants have significant direct and indirect adverse effects on public health. To explore the relationship between air pollutants and meteorological conditions on the hospitalization for respiratory diseases, we collected a whole year of daily major air pollutants' concentrations from Shenzhen city in 2013, including Particulate Matter (PM10, PM2.5), Nitrogen dioxide (NO2), Ozone (O3), Sulphur dioxide (SO2), and Carbon monoxide (CO). Meanwhile, we also gained meteorological data. This study collected 109,927 patients cases with diseases of the respiratory system from 98 hospitals. We investigated the influence of meteorological factors on air pollution by Spearman correlation analysis. Then, we tested the short-term correlation between significant air pollutants and respiratory diseases' hospitalization by Distributed Lag Non-linear Model (DLNM). There was a significant negative correlation between the north wind and NO2 and a significant negative correlation between the south wind and six pollutants. Except for CO, other air pollutants were significantly correlated with the number of hospitalized patients during the lag period. Most of the pollutants reached maximum Relative Risk (RR) with a lag of five days. When the time lag was five days, the annual average of PM10, PM2.5, SO2, NO2, and O3 increased by 10%, and the risk of hospitalization for the respiratory system increased by 0.29%, 0.23%, 0.22%, 0.25%, and 0.22%, respectively. All the pollutants except CO impact the respiratory system's hospitalization in a short period, and PM10 has the most significant impact. The results are helpful for pollution control from a public health perspective.