Biomaterial Database

Corynebacterium aquaticum infection in a patient with chronic granulomatous disease. 1988

A Kaplan, and F Israel

Department of Pediatrics, University of North Carolina, Chapel Hill 27514.

Patients with chronic granulomatous disease are uniquely susceptible to infection with catalase-producing bacteria. Staphylococcus aureus, Klebsiella, Escherichia coli and Serratia marcescans are common infecting organisms. A 17-month-old boy with Corynebacterium aquaticum bacteremia is reported. This is only the third documented infection with this non-JK diphtheroid and the first case infection in a patient with chronic granulomatous disease. It is likely that our patient's underlying immune defect predisposed him to infection with this unusual, catalase-producing organism. Although these bacteria are common contaminants and rarely infecting agents, true infection should be considered in patients with chronic granulomatous disease from whom a diphtheroid is isolated.

UI	MeSH Term	Description	Entries
D007223	Infant	A child between 1 and 23 months of age.	Infants
D008297	Male		Males
D003352	Corynebacterium	A genus of asporogenous bacteria that is widely distributed in nature. Its organisms appear as straight to slightly curved rods and are known to be human and animal parasites and pathogens.
D003354	Corynebacterium Infections	Infections with bacteria of the genus CORYNEBACTERIUM.	Infections, Corynebacterium,Corynebacterium Infection,Infection, Corynebacterium
D006105	Granulomatous Disease, Chronic	A defect of leukocyte function in which phagocytic cells ingest but fail to digest bacteria, resulting in recurring bacterial infections with granuloma formation. When chronic granulomatous disease is caused by mutations in the CYBB gene, the condition is inherited in an X-linked recessive pattern. When chronic granulomatous disease is caused by CYBA, NCF1, NCF2, or NCF4 gene mutations, the condition is inherited in an autosomal recessive pattern.	Autosomal Recessive Chronic Granulomatous Disease,Chronic Granulomatous Disease,Chronic Granulomatous Disease, Atypical,Chronic Granulomatous Disease, X-Linked,Cytochrome B-Negative Granulomatous Disease, Chronic, X-Linked,Cytochrome B-Positive Granulomatous Disease, Chronic, X-Linked,Granulomatous Disease, Chronic, X-Linked,Granulomatous Disease, Chronic, X-Linked, Variant,X-Linked Chronic Granulomatous Disease,Chronic Granulomatous Disease, X Linked,Chronic Granulomatous Diseases,Granulomatous Diseases, Chronic,X Linked Chronic Granulomatous Disease
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D018805	Sepsis	Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.	Bloodstream Infection,Pyaemia,Pyemia,Pyohemia,Blood Poisoning,Poisoning, Blood,Septicemia,Severe Sepsis,Blood Poisonings,Bloodstream Infections,Infection, Bloodstream,Poisonings, Blood,Pyaemias,Pyemias,Pyohemias,Sepsis, Severe,Septicemias