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Total serum cholesterol and plasma lipoprotein cholesterol concentrations in cord sera of newborns from hispanic mothers with gestational diabetes. 1988

T C Chan, and J J Schwartz, and R E Garcia, and H P Chin, and R Barndt
Department of Chemistry and Biochemistry, California State University, Los Angeles 90032.

The objective of this research was to determine if gestational diabetes has an impact on the plasma lipoprotein profiles and/or cholesterol content of the plasma lipoproteins in newborns. Very low plus low density lipoproteins and high density lipoproteins in cord sera of newborns from gestational diabetic and non-diabetic mothers were isolated by heparin-affinity chromatography, and the cholesterol content in these plasma lipoprotein fractions were measured with an enzymatic assay. There were no significant differences in baby weights and total serum cholesterol levels between the two experimental groups. High density lipoprotein cholesterol levels (p less than 0.05) were significantly lower while very low plus low density lipoprotein cholesterol concentrations (p less than 0.05), very low plus low density lipoprotein cholesterol/high density lipoprotein cholesterol ratios (p less than 0.025), and total serum cholesterol/high density lipoprotein cholesterol ratios (p less than 0.025) were significantly elevated in newborns of diabetic mothers. These results suggest that gestational diabetes altered neonatal plasma lipoprotein metabolism.

UI MeSH Term Description Entries
D007231 Infant, Newborn An infant during the first 28 days after birth. Neonate,Newborns,Infants, Newborn,Neonates,Newborn,Newborn Infant,Newborn Infants
D008076 Cholesterol, HDL Cholesterol which is contained in or bound to high-density lipoproteins (HDL), including CHOLESTEROL ESTERS and free cholesterol. High Density Lipoprotein Cholesterol,Cholesterol, HDL2,Cholesterol, HDL3,HDL Cholesterol,HDL(2) Cholesterol,HDL(3) Cholesterol,HDL2 Cholesterol,HDL3 Cholesterol,alpha-Lipoprotein Cholesterol,Cholesterol, alpha-Lipoprotein,alpha Lipoprotein Cholesterol
D008297 Male Males
D009994 Osmolar Concentration The concentration of osmotically active particles in solution expressed in terms of osmoles of solute per liter of solution. Osmolality is expressed in terms of osmoles of solute per kilogram of solvent. Ionic Strength,Osmolality,Osmolarity,Concentration, Osmolar,Concentrations, Osmolar,Ionic Strengths,Osmolalities,Osmolar Concentrations,Osmolarities,Strength, Ionic,Strengths, Ionic
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D011254 Pregnancy in Diabetics The state of PREGNANCY in women with DIABETES MELLITUS. This does not include either symptomatic diabetes or GLUCOSE INTOLERANCE induced by pregnancy (DIABETES, GESTATIONAL) which resolves at the end of pregnancy. Pregnancy in Diabetes,Pregnancy in Diabete,Pregnancy in Diabetic
D012016 Reference Values The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality. Normal Range,Normal Values,Reference Ranges,Normal Ranges,Normal Value,Range, Normal,Range, Reference,Ranges, Normal,Ranges, Reference,Reference Range,Reference Value,Value, Normal,Value, Reference,Values, Normal,Values, Reference
D002784 Cholesterol The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils. Epicholesterol
D002845 Chromatography Techniques used to separate mixtures of substances based on differences in the relative affinities of the substances for mobile and stationary phases. A mobile phase (fluid or gas) passes through a column containing a stationary phase of porous solid or liquid coated on a solid support. Usage is both analytical for small amounts and preparative for bulk amounts. Chromatographies
D003720 Densitometry The measurement of the density of a material by measuring the amount of light or radiation passing through (or absorbed by) the material. Densitometries

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