The indole alkaloids from the roots of Isatidis Radix. 2021

Faqin Wang, and Jingting Bi, and Liwei He, and Jing Chen, and Qiangzi Zhang, and Xianbang Hou, and Huiqin Xu
Department of Pharmacology, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China; Department of Pharmacology, Nanjing University of Chinese Medicine Hanlin College, Taizhou 225312, China. Electronic address: 253429838@qq.com.

The root of Isatis indigotica is used as a traditional Chinese medicine (termed Isatidis Radix) due to its antiviral effects. We examined compounds isolated from Isatidis Radix and elucidated the structures of three new natural alkaloids, and we examined the possible mechanisms or active targets of indole alkaloids occurring in blood of rats treated by gavage. Three new natural products were isolated from Radix Isatidis for the first time, including 1-methoxy-2-indoleacetonitrile, 1-hydroxy-3-indoleacetonitrile, 8-Methoxy-1, 2-dihydroquinoline, and 4 compounds isolated from this medicinal material for the first time. Their structures were elucidated using nuclear magnetic resonance. The components of Isatidis Radix were analysed using liquid chromatography tandem mass spectrometry, and 33 compounds were detected in plasma of treated rats; 24 of these compounds were indole alkaloids, and they included the newly identified compounds. Molecular docking and in vitro antithrombin activity tests showed HA inhibition activity of indoleacetonitriles.

UI MeSH Term Description Entries
D008297 Male Males
D002681 China A country spanning from central Asia to the Pacific Ocean. Inner Mongolia,Manchuria,People's Republic of China,Sinkiang,Mainland China
D004365 Drugs, Chinese Herbal Chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China. Chinese Herbal Drugs,Plant Extracts, Chinese,Chinese Drugs, Plant,Chinese Plant Extracts,Extracts, Chinese Plant,Herbal Drugs, Chinese
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000998 Antiviral Agents Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. Antiviral,Antiviral Agent,Antiviral Drug,Antivirals,Antiviral Drugs,Agent, Antiviral,Agents, Antiviral,Drug, Antiviral,Drugs, Antiviral
D015394 Molecular Structure The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds. Structure, Molecular,Molecular Structures,Structures, Molecular
D017207 Rats, Sprague-Dawley A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company. Holtzman Rat,Rats, Holtzman,Sprague-Dawley Rat,Rats, Sprague Dawley,Holtzman Rats,Rat, Holtzman,Rat, Sprague-Dawley,Sprague Dawley Rat,Sprague Dawley Rats,Sprague-Dawley Rats
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus
D062105 Molecular Docking Simulation A computer simulation technique that is used to model the interaction between two molecules. Typically the docking simulation measures the interactions of a small molecule or ligand with a part of a larger molecule such as a protein. Molecular Docking,Molecular Docking Simulations,Molecular Docking Analysis,Analysis, Molecular Docking,Docking Analysis, Molecular,Docking Simulation, Molecular,Docking, Molecular,Molecular Docking Analyses,Molecular Dockings,Simulation, Molecular Docking
D018517 Plant Roots The usually underground portions of a plant that serve as support, store food, and through which water and mineral nutrients enter the plant. (From American Heritage Dictionary, 1982; Concise Dictionary of Biology, 1990) Plant Bulbs,Plant Root,Bulb, Plant,Bulbs, Plant,Plant Bulb,Root, Plant,Roots, Plant

Related Publications

Faqin Wang, and Jingting Bi, and Liwei He, and Jing Chen, and Qiangzi Zhang, and Xianbang Hou, and Huiqin Xu
October 2004, Journal of natural products,
Faqin Wang, and Jingting Bi, and Liwei He, and Jing Chen, and Qiangzi Zhang, and Xianbang Hou, and Huiqin Xu
January 2022, Natural product research,
Faqin Wang, and Jingting Bi, and Liwei He, and Jing Chen, and Qiangzi Zhang, and Xianbang Hou, and Huiqin Xu
August 2011, Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica,
Faqin Wang, and Jingting Bi, and Liwei He, and Jing Chen, and Qiangzi Zhang, and Xianbang Hou, and Huiqin Xu
December 2006, Yao xue xue bao = Acta pharmaceutica Sinica,
Faqin Wang, and Jingting Bi, and Liwei He, and Jing Chen, and Qiangzi Zhang, and Xianbang Hou, and Huiqin Xu
January 2006, Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban,
Faqin Wang, and Jingting Bi, and Liwei He, and Jing Chen, and Qiangzi Zhang, and Xianbang Hou, and Huiqin Xu
May 1990, Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica,
Faqin Wang, and Jingting Bi, and Liwei He, and Jing Chen, and Qiangzi Zhang, and Xianbang Hou, and Huiqin Xu
January 2012, Journal of Asian natural products research,
Faqin Wang, and Jingting Bi, and Liwei He, and Jing Chen, and Qiangzi Zhang, and Xianbang Hou, and Huiqin Xu
May 2023, Journal of Asian natural products research,
Faqin Wang, and Jingting Bi, and Liwei He, and Jing Chen, and Qiangzi Zhang, and Xianbang Hou, and Huiqin Xu
October 2010, Fitoterapia,
Faqin Wang, and Jingting Bi, and Liwei He, and Jing Chen, and Qiangzi Zhang, and Xianbang Hou, and Huiqin Xu
November 2017, Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica,
Copied contents to your clipboard!