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2-Amino-3-methylimidazo[4,5-f]quinoline (IQ), a potent bacterial mutagen present in broiled sardines, cooked beef and beef extract, is a carcinogen in the F-344 rat, affecting mainly the liver and small and large intestines. Using 32P-postlabeling assays, the formation of IQ-DNA adducts was examined in male F-344 rats. Twenty-four hours after i.p. doses (5-50 mg IQ/kg) the liver, small and large intestine each showed the presence of 5 adducts, the liver and large intestine having an average of 18.1 and 2.4 times as many adducts, respectively, as the small intestine. None of these adducts could be detected in vehicle-treated animals. It is concluded that IQ forms specific DNA adducts in target tissues of the F-344 rat.
H A Schut, and
K L Putman, and
K Randerath
February 2001,
The journal of medical investigation : JMI,
H A Schut, and
K L Putman, and
K Randerath
October 1994,
Environmental health perspectives,
H A Schut, and
K L Putman, and
K Randerath
July 1995,
Cancer research,
H A Schut, and
K L Putman, and
K Randerath
March 1996,
Chemical research in toxicology,
H A Schut, and
K L Putman, and
K Randerath
September 1995,
Carcinogenesis,
H A Schut, and
K L Putman, and
K Randerath
January 1994,
Chemical research in toxicology,
H A Schut, and
K L Putman, and
K Randerath
May 1991,
Carcinogenesis,
H A Schut, and
K L Putman, and
K Randerath
October 1991,
Cancer research,
H A Schut, and
K L Putman, and
K Randerath
January 1986,
IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans,
H A Schut, and
K L Putman, and
K Randerath
January 1993,
IARC monographs on the evaluation of carcinogenic risks to humans,
