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1. Elevated levels of metallothionein (MT)-I and -II were identified in the liver and kidney of insulin-deficient diabetic rats. 2. The relative rate of MT synthesis and the turnover of cytoplasmic MT were both accelerated in the liver of diabetic rats. 3. The rate of synthesis of MT, but not its cytoplasmic turnover, was increased in diabetic kidney. 4. Maximal relative rates of MT synthesis in liver and kidney were first observed at 4 and 10 days, respectively, after inducing the diabetic condition. 5. The altered metabolism of hepatic MT in diabetic rats was attributed primarily to disturbances in endocrine status, while the altered metabolism of renal MT was largely due to accumulation of excessive dietary copper in the kidney.
M L Chen, and
M L Failla
January 1993,
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine,
M L Chen, and
M L Failla
October 1982,
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society,
M L Chen, and
M L Failla
December 2012,
Biological trace element research,
M L Chen, and
M L Failla
April 1991,
Biochemical Society transactions,
M L Chen, and
M L Failla
May 1985,
The Biochemical journal,
M L Chen, and
M L Failla
January 2014,
American journal of physiology. Renal physiology,
M L Chen, and
M L Failla
January 2004,
Nephron. Experimental nephrology,
M L Chen, and
M L Failla
March 1979,
Chemical & pharmaceutical bulletin,
M L Chen, and
M L Failla
January 1980,
Reproduccion,
M L Chen, and
M L Failla
December 1980,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
