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Pharmacokinetics of Orally Administered GS-441524 in Dogs. 2021
Victoria C Yan, and
Cong-Dat Pham, and
Matthew J Yan, and
Alexander J Yan, and
Sunada Khadka, and
Kenisha Arthur, and
Jeffrey J Ackroyd, and
Dimitra K Georgiou, and
Laura E Roon, and
Lane R Bushman, and
Peter L Anderson, and
Chun Li, and
Florian L Muller
Copycat Sciences, Boston, MA, USA.
Despite being FDA-approved for COVID-19, the clinical efficacy of remdesivir (Veklury®) remains contentious. We previously pointed out pharmacokinetic, pharmacodynamic and toxicology reasons for why its parent nucleoside GS-441524, is better suited for COVID-19 treatment. Here, we assess the oral bioavailability of GS-441524 in beagle dogs and show that plasma concentrations ~24-fold higher than the EC50 against SARS-CoV-2 are easily and safely sustained. These data support translation of GS-441524 as an oral agent for COVID-19.
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