The effect of verapamil on cerebral cortical and spinal cord blood flow during proximal descending thoracic aortic occlusion. 1988

A C Hill, and W P Schecter, and H Mori, and M B Stevens, and W Husseni, and R C Lim, and J I Hoffman
Cardiovascular Research Institute, University of California, San Francisco.

The mechanism of central nervous system (CNS) protection during proximal descending thoracic aortic cross-clamping (PDTAC) for aortic surgery using calcium channel blocking agents is not known. In order to determine the effect of verapamil on CNS blood flow during PDTAC, we calculated cerebral cortical (CC), proximal spinal cord (PSC), and distal spinal cord (DSC) blood flow using the microsphere method in Grade I beagles. Flow calculations were obtained at baseline (pre-PDTAC), following mobilization of the proximal descending aorta for 5-8 cm by ligating 3-5 pairs of intercostal arteries (ICA), during PDTAC (45 min), and during maximal reperfusion. Two groups were studied: 1) control (Cont) untreated (n = 5); 2) verapamil (Ver) treated (0.4 mg/kg IV just before PDTAC and just before reperfusion) (n = 5). CONCLUSIONS I) Proximal ICA ligation produces no compromise to SC blood flow. II) Verapamil may protect the CNS by: 1) maintaining cerebral autoregulation during reperfusion; and 2) dampening hyperperfusion of the distal SC during reperfusion.

UI MeSH Term Description Entries
D006973 Hypertension Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more. Blood Pressure, High,Blood Pressures, High,High Blood Pressure,High Blood Pressures
D007022 Hypotension Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients. Blood Pressure, Low,Hypotension, Vascular,Low Blood Pressure,Vascular Hypotension
D007511 Ischemia A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION. Ischemias
D008863 Microspheres Small uniformly-sized spherical particles, of micrometer dimensions, frequently labeled with radioisotopes or various reagents acting as tags or markers. Latex Beads,Latex Particles,Latex Spheres,Microbeads,Bead, Latex,Beads, Latex,Latex Bead,Latex Particle,Latex Sphere,Microbead,Microsphere,Particle, Latex,Particles, Latex,Sphere, Latex,Spheres, Latex
D012039 Regional Blood Flow The flow of BLOOD through or around an organ or region of the body. Blood Flow, Regional,Blood Flows, Regional,Flow, Regional Blood,Flows, Regional Blood,Regional Blood Flows
D002540 Cerebral Cortex The thin layer of GRAY MATTER on the surface of the CEREBRAL HEMISPHERES that develops from the TELENCEPHALON and folds into gyri and sulci. It reaches its highest development in humans and is responsible for intellectual faculties and higher mental functions. Allocortex,Archipallium,Cortex Cerebri,Cortical Plate,Paleocortex,Periallocortex,Allocortices,Archipalliums,Cerebral Cortices,Cortex Cerebrus,Cortex, Cerebral,Cortical Plates,Paleocortices,Periallocortices,Plate, Cortical
D003250 Constriction The act of constricting. Clamping,Clampings,Constrictions
D004285 Dogs The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065) Canis familiaris,Dog
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001013 Aorta, Thoracic The portion of the descending aorta proceeding from the arch of the aorta and extending to the DIAPHRAGM, eventually connecting to the ABDOMINAL AORTA. Aorta, Ascending,Aorta, Descending,Aortic Arch,Aortic Root,Arch of the Aorta,Descending Aorta,Sinotubular Junction,Ascending Aorta,Thoracic Aorta,Aortic Roots,Arch, Aortic,Ascending Aortas,Junction, Sinotubular,Root, Aortic,Sinotubular Junctions

Related Publications

A C Hill, and W P Schecter, and H Mori, and M B Stevens, and W Husseni, and R C Lim, and J I Hoffman
October 2004, Masui. The Japanese journal of anesthesiology,
A C Hill, and W P Schecter, and H Mori, and M B Stevens, and W Husseni, and R C Lim, and J I Hoffman
April 2001, The Journal of cardiovascular surgery,
A C Hill, and W P Schecter, and H Mori, and M B Stevens, and W Husseni, and R C Lim, and J I Hoffman
February 2003, Journal of vascular surgery,
A C Hill, and W P Schecter, and H Mori, and M B Stevens, and W Husseni, and R C Lim, and J I Hoffman
September 1982, The Annals of thoracic surgery,
A C Hill, and W P Schecter, and H Mori, and M B Stevens, and W Husseni, and R C Lim, and J I Hoffman
February 2001, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
A C Hill, and W P Schecter, and H Mori, and M B Stevens, and W Husseni, and R C Lim, and J I Hoffman
October 1988, Journal of vascular surgery,
A C Hill, and W P Schecter, and H Mori, and M B Stevens, and W Husseni, and R C Lim, and J I Hoffman
January 2016, Hippokratia,
A C Hill, and W P Schecter, and H Mori, and M B Stevens, and W Husseni, and R C Lim, and J I Hoffman
June 2010, Interactive cardiovascular and thoracic surgery,
A C Hill, and W P Schecter, and H Mori, and M B Stevens, and W Husseni, and R C Lim, and J I Hoffman
August 2012, Scandinavian cardiovascular journal : SCJ,
A C Hill, and W P Schecter, and H Mori, and M B Stevens, and W Husseni, and R C Lim, and J I Hoffman
January 2016, Seminars in thoracic and cardiovascular surgery,
Copied contents to your clipboard!