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Forty-three patients with inoperable and/or recurring malignant gliomas and 30 patients with multiple recurring brain metastases were treated with a combination of adriamycine (45 mg/m 2 and 4-dimethyl-epipodophyllotoxin D-thenylidene (VM 26) (60 mg/m 2 for 2 days) and 1-(2-chloroethyl)-3-cyclohexyl-1-nitroso-urea (CCNU) (60 mg/m 2 for 2 days). These cycles of treatment were repeated as soon as the hematologic restoration was complete. The treatment was well-tolerated and the clinical condition of 31 out of 43 glioblastoma patients improved during the 2 months after the beginning of the treatment. Six out of eight patients with breast cancer metastases, one out of 13 with bronchial cancer metastases, and three out of nine with other types of cancer metastases also benefitted from the treatment. Examination of the results reveals the following characteristics: 1. A low degree of efficiency of this combination in the treatment of brain metastases, except for breast cancer metastases. 2. Absence of complete correlation between the clinical results observed and the cinegammagraphic developments 3. Similarity of the results independent of the initial localization 4. Establishment of a 6-month median survival period, with ten patients at present in a state of apparently complete remission, 180-506 days after beginning of the treatment.
P Pouillart, and
G Mathé, and
T Palangie, and
J Lheritier, and
M Poisson, and
P Huguenin, and
H Gautier, and
P Morin, and
R Parrot
January 1977,
European journal of cancer,
P Pouillart, and
G Mathé, and
T Palangie, and
J Lheritier, and
M Poisson, and
P Huguenin, and
H Gautier, and
P Morin, and
R Parrot
November 1976,
Cancer,
P Pouillart, and
G Mathé, and
T Palangie, and
J Lheritier, and
M Poisson, and
P Huguenin, and
H Gautier, and
P Morin, and
R Parrot
February 1976,
La Nouvelle presse medicale,
P Pouillart, and
G Mathé, and
T Palangie, and
J Lheritier, and
M Poisson, and
P Huguenin, and
H Gautier, and
P Morin, and
R Parrot
March 1979,
Surgical neurology,
P Pouillart, and
G Mathé, and
T Palangie, and
J Lheritier, and
M Poisson, and
P Huguenin, and
H Gautier, and
P Morin, and
R Parrot
March 1980,
Helvetica paediatrica acta,
P Pouillart, and
G Mathé, and
T Palangie, and
J Lheritier, and
M Poisson, and
P Huguenin, and
H Gautier, and
P Morin, and
R Parrot
December 1977,
Cancer treatment reports,
P Pouillart, and
G Mathé, and
T Palangie, and
J Lheritier, and
M Poisson, and
P Huguenin, and
H Gautier, and
P Morin, and
R Parrot
April 1992,
Journal of chemotherapy (Florence, Italy),
P Pouillart, and
G Mathé, and
T Palangie, and
J Lheritier, and
M Poisson, and
P Huguenin, and
H Gautier, and
P Morin, and
R Parrot
March 1979,
Cancer treatment reports,
P Pouillart, and
G Mathé, and
T Palangie, and
J Lheritier, and
M Poisson, and
P Huguenin, and
H Gautier, and
P Morin, and
R Parrot
December 1977,
Cancer treatment reports,
P Pouillart, and
G Mathé, and
T Palangie, and
J Lheritier, and
M Poisson, and
P Huguenin, and
H Gautier, and
P Morin, and
R Parrot
January 1977,
European journal of cancer,
