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We present an unusual case of primary aldosteronism in childhood. A 9-year-old boy had hypertension, hypokalemia, hyporeninemia and hyperaldosteronism. Dexamethasone administration decreased plasma aldosterone transiently but failed to correct the hyperaldosteronism, excluding dexamethasone-suppressible hyperaldosteronism. Plasma aldosterone decreased with upright posture and showed a circadian rhythm. Spironolactone treatment normalized blood pressure and serum potassium and lowered aldosterone secretion. During the studies, plasma aldosterone correlated with serum cortisol but not with plasma renin. Preoperative results indicated that this patient presented the functional features of aldosteronoma. Adrenal computed tomography, scintigraphy and left venography were not diagnostic of adrenal lesions. The left adrenal venous sampling showed hypersecretion of aldosterone from the left adrenal gland. The left adrenalectomy revealed micronodular hyperplasia but resulted in a prompt and sustained reversal of hypertension and hyperaldosteronism. These findings suggest that primary aldosteronism in this patient resulted from primary adrenal hyperplasia. Thus, adrenal hyperplasia is a heterogenous group of disorders and carefully selected studies allow prospective selection of appropriate treatment.
Y Kikuta, and
K Sanjo, and
K Nakajima, and
I Ashizawa, and
M Ojima
November 1980,
The Journal of clinical endocrinology and metabolism,
Y Kikuta, and
K Sanjo, and
K Nakajima, and
I Ashizawa, and
M Ojima
May 2006,
Nihon rinsho. Japanese journal of clinical medicine,
Y Kikuta, and
K Sanjo, and
K Nakajima, and
I Ashizawa, and
M Ojima
September 1998,
Journal of endocrinological investigation,
Y Kikuta, and
K Sanjo, and
K Nakajima, and
I Ashizawa, and
M Ojima
April 2005,
Hypertension research : official journal of the Japanese Society of Hypertension,
Y Kikuta, and
K Sanjo, and
K Nakajima, and
I Ashizawa, and
M Ojima
February 1997,
Zhonghua yi xue za zhi = Chinese medical journal; Free China ed,
Y Kikuta, and
K Sanjo, and
K Nakajima, and
I Ashizawa, and
M Ojima
August 1956,
Lancet (London, England),
Y Kikuta, and
K Sanjo, and
K Nakajima, and
I Ashizawa, and
M Ojima
May 1984,
Klinische Wochenschrift,
Y Kikuta, and
K Sanjo, and
K Nakajima, and
I Ashizawa, and
M Ojima
April 2022,
Cureus,
Y Kikuta, and
K Sanjo, and
K Nakajima, and
I Ashizawa, and
M Ojima
July 1959,
A.M.A. journal of diseases of children,
Y Kikuta, and
K Sanjo, and
K Nakajima, and
I Ashizawa, and
M Ojima
March 1980,
Pediatrics,
