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A clinical trial of the drug "Rocaltrol" was carried out on 16 patients with osteoporosis, II of them with menopause osteoporosis and 5 with steroid-induced osteoporosis. The mean age of the patients was 53.1 +/- 11.1 years. The mean daily dose of the drug was 0.46 +/- 0.08 mg/24h. The treatment lasted 6 months. All patients showed improvement of the general condition and of calcium balance. Reliable increase of the total calcium and phosphorus levels and of the 24-hour calcium urine excretion were established, the maximal values being at the end of the third month. The X-ray examination showed stabilization of the bone changes and lack of new compression fractures. It is supposed that the drug improves the intestinal resorption of calcium and phosphorus and suppresses the bone resorption. This is proved by the reliable decrease of serum alkaline phosphatase level after the 6 month treatment. In all patients clinical improvement was established with diminishing of the bone aches and retaining the body height before and after the treatment.
D Koev, and
S Todorova, and
L Diankov, and
D Khristova, and
K Tsachev
February 1979,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
D Koev, and
S Todorova, and
L Diankov, and
D Khristova, and
K Tsachev
January 1993,
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA,
D Koev, and
S Todorova, and
L Diankov, and
D Khristova, and
K Tsachev
August 1987,
British journal of haematology,
D Koev, and
S Todorova, and
L Diankov, and
D Khristova, and
K Tsachev
April 1999,
Der Internist,
D Koev, and
S Todorova, and
L Diankov, and
D Khristova, and
K Tsachev
July 1993,
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA,
D Koev, and
S Todorova, and
L Diankov, and
D Khristova, and
K Tsachev
March 1991,
Annals of internal medicine,
D Koev, and
S Todorova, and
L Diankov, and
D Khristova, and
K Tsachev
January 1995,
Srpski arhiv za celokupno lekarstvo,
D Koev, and
S Todorova, and
L Diankov, and
D Khristova, and
K Tsachev
October 1998,
Steroids,
D Koev, and
S Todorova, and
L Diankov, and
D Khristova, and
K Tsachev
January 1990,
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
D Koev, and
S Todorova, and
L Diankov, and
D Khristova, and
K Tsachev
January 1999,
International journal of clinical pharmacology research,
