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Immunological Correlates of the HIV-1 Replication-Competent Reservoir Size. 2021
Sherazaan D Ismail, and
Catherine Riou, and
Sarah B Joseph, and
Nancie M Archin, and
David M Margolis, and
Alan S Perelson, and
Tyler Cassidy, and
Melissa-Rose Abrahams, and
Matthew Moeser, and
Olivia D Council, and
Lyle R McKinnon, and
Farzana Osman, and
Quarraisha Abdool Karim, and
Salim S Abdool Karim, and
Ronald Swanstrom, and
Carolyn Williamson, and
Nigel J Garrett, and
Wendy A Burgers
Division of Medical Virology, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Understanding what shapes the latent human immunodeficiency virus type 1 (HIV-1) reservoir is critical for developing strategies for cure. We measured frequency of persistent HIV-1 infection after 5 years of suppressive antiretroviral therapy initiated during chronic infection. Pretreatment CD8+ T-cell activation, nadir CD4 count, and CD4:CD8 ratio predicted reservoir size.
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